PDF DatasheetHuman Potassium channel subfamily K member 2 Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant Potassium channel subfamily K member 2 based upon sequence from: Human
Host: QP9230 protein expressed in Yeast.
Tag: His
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) Potassium channel subfamily K member 2, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP9230.
Bioactivity Data: Untested
Full Length? Partial (see sequence information for more details).
Expression Region: Met1 – Asp143
Amino Acid Sequence: MLPSASRERP GYRAGVAAPD LLDPKSAAQN SKPRLSFSTK PTVLASRVES DTTINVMKWK TVSTIFLVVV LYLIIGATVF KALEQPHEIS QRTTIVIQKQ TFISQHSCVN STELDELIQQ IVAAINAGII PLGNTSNQIS HWD
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human Potassium channel subfamily K member 2 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human Potassium channel subfamily K member 2 Protein General Information | |
|---|---|
| Alternate Names | |
| K2p2.1; TREK; hTREK-1c; TPKC1; hTREK-1e; TREK-1; TREK1 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | KCNK2 |
| Entrez Gene ID | 3776 |
| Ensemble Gene ID | ENSG00000082482 |
| RefSeq Protein Accession(s) | NP_001017424.1 |
| RefSeq mRNA Accession(s) | NM_001017424.2, NM_001017425.2, NM_014217.3, XM_017001248.1 |
| UniProt ID(s) | O95069 |
| UniGene ID(s) | Hs.497745 |
| HGNC ID(s) | HGNC:6277 |
| COSMIC ID Link(s) | KCNK2 |
| KEGG Gene ID(s) | hsa:3776 |
| PharmGKB ID(s) | PA30059 |
| General Description of Recombinant Human Potassium channel subfamily K member 2 Protein. | |
| Ion channel that contributes to passive transmembrane potassium transport (PubMed:23169818). Reversibly converts between a voltage-insensitive potassium leak channel and a voltage-dependent outward rectifying potassium channel in a phosphorylation-dependent manner (PubMed:11319556). In astrocytes, forms mostly heterodimeric potassium channels with KCNK1, with only a minor proportion of functional channels containing homodimeric KCNK2. In astrocytes, the heterodimer formed by KCNK1 and KCNK2 is required for rapid glutamate release in response to activation of G-protein coupled receptors, such as F2R and CNR1 | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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