PDF DatasheetHuman LGR5 Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant LGR5 based upon sequence from: Human
Host: QP9247 protein expressed in Yeast.
Tag: His
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) LGR5, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP9247.
Bioactivity Data: Untested
Full Length? Partial (see sequence information for more details).
Expression Region: Gly22 – Arg561
Amino Acid Sequence: GSSPRSGVLL RGCPTHCHCE PDGRMLLRVD CSDLGLSELP SNLSVFTSYL DLSMNNISQL LPNPLPSLRF LEELRLAGNA LTYIPKGAFT GLYSLKVLML QNNQLRHVPT EALQNLRSLQ SLRLDANHIS YVPPSCFSGL HSLRHLWLDD NALTEIPVQA FRSLSALQAM TLALNKIHHI PDYAFGNLSS LVVLHLHNNR IHSLGKKCFD GLHSLETLDL NYNNLDEFPT AIRTLSNLKE LGFHSNNIRS IPEKAFVGNP SLITIHFYDN PIQFVGRSAF QHLPELRTLT LNGASQITEF PDLTGTANLE SLTLTGAQIS SLPQTVCNQL PNLQVLDLSY NLLEDLPSFS VCQKLQKIDL RHNEIYEIKV DTFQQLLSLR SLNLAWNKIA IIHPNAFSTL PSLIKLDLSS NLLSSFPITG LHGLTHLKLT GNHALQSLIS SENFPELKVI EMPYAYQCCA FGVCENAYKI SNQWNKGDNS SMDDLHKKDA GMFQAQDERD LEDFLLDFEE DLKALHSVQC SPSPGPFKPC EHLLDGWLIR
Purity: Greater than 80% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human LGR5 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human LGR5 Protein General Information | |
|---|---|
| Alternate Names | |
| FEX; GPR67; HG38; GPR49; GRP49; Leucine-rich repeat-containing G-protein coupled receptor | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | LGR5 |
| Entrez Gene ID | 8549 |
| Ensemble Gene ID | ENSG00000139292 |
| RefSeq Protein Accession(s) | NP_001264155.1 |
| RefSeq mRNA Accession(s) | NM_001277226.1, NM_001277227.1, NM_003667.3 |
| UniProt ID(s) | O75473 |
| UniGene ID(s) | Hs.658889 |
| HGNC ID(s) | HGNC:4504 |
| COSMIC ID Link(s) | LGR5 |
| KEGG Gene ID(s) | hsa:8549 |
| PharmGKB ID(s) | PA28894 |
| General Description of Recombinant Human LGR5 Protein. | |
| Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and acts as a st cell marker of the intestinal epithelium and the hair follicle. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by Extracellular domain Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal. Involved in the development and/or maintenance of the adult intestinal st cells during postbryonic development. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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