PDF DatasheetHuman Protein-methionine sulfoxide oxidase MICAL2 Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant Protein-methionine sulfoxide oxidase MICAL2 based upon sequence from: Human
Host: QP9273 protein expressed in Yeast.
Tag: His
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) Protein-methionine sulfoxide oxidase MICAL2, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP9273.
Bioactivity Data: Untested
Full Length? Partial (see sequence information for more details).
Expression Region: Met1 – His495
Amino Acid Sequence: MGENEDEKQA QAGQVFENFV QASTCKGTLQ AFNILTRHLD LDPLDHRNFY SKLKSKVTTW KAKALWYKLD KRGSHKEYKR GKSCTNTKCL IVGGGPCGLR TAIELAYLGA KVVVVEKRDS FSRNNVLHLW PFTIHDLRGL GAKKFYGKFC AGSIDHISIR QLQLILFKVA LMLGVEIHVN VEFVKVLEPP EDQENQKIGW RAEFLPTDHS LSEFEFDVII GADGRRNTLE GFRRKEFRGK LAIAITANFI NRNSTAEAKV EEISGVAFIF NQKFFQDLKE ETGIDLENIV YYKDCTHYFV MTAKKQSLLD KGVIINDYID TEMLLCAENV NQDNLLSYAR EAADFATNYQ LPSLDFAMNH YGQPDVAMFD FTCMYASENA ALVRERQAHQ LLVALVGDSL LEPFWPMGTG CARGFLAAFD TAWMVKSWNQ GTPPLELLAE RESLYRLLPQ TTPENINKNF EQYTLDPGTR YPNLNSHCVR PHQVKHLYIT KELEH
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human Protein-methionine sulfoxide oxidase MICAL2 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human Protein-methionine sulfoxide oxidase MICAL2 Protein General Information | |
|---|---|
| Alternate Names | |
| MICAL-2; MICAL2PV2; MICAL2PV1 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | MICAL2 |
| Entrez Gene ID | 9645 |
| Ensemble Gene ID | ENSG00000133816 |
| RefSeq Protein Accession(s) | NP_001269592.1 |
| RefSeq mRNA Accession(s) | NM_001282663.1, NM_001282664.1, NM_001282665.1, NM_001282666.1, NM_001282667.1, NM_001346292.1, NM_001346293.1, NM_001346294.1, NM_001346295.1, NM_001346296.1, NM_001346297.1, NM_001346298.1, NM_001346299.1, NM_014632.3, XM_017018589.1, XM_017018590.1, XM_017018591.1 |
| UniProt ID(s) | O94851 |
| UniGene ID(s) | Hs.501928 |
| HGNC ID(s) | HGNC:24693 |
| COSMIC ID Link(s) | MICAL2 |
| KEGG Gene ID(s) | hsa:9645 |
| PharmGKB ID(s) | PA142671453 |
| General Description of Recombinant Human Protein-methionine sulfoxide oxidase MICAL2 Protein. | |
| Nuclear monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin and regulates the SRF signaling. Acts by modifying nuclear actin subunits through the addition of oxygen to form methionine-sulfoxide, leading to promote actin filament severing and prevent repolymerization. Acts as a key regulator of the SRF signaling pathway elicited by nerve growth factor and serum: mediates oxidation and subsequent depolymerization of nuclear actin, leading to increase MKL1/MRTF-A presence in the nucleus and promote SRF:MKL1/MRTF-A-dependent gene transcription. Does not activate SRF:MKL1/MRTF-A through RhoA. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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