PDF DatasheetHuman Cardiac phospholamban Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant Cardiac phospholamban based upon sequence from: Human
Host: QP9335 protein expressed in Yeast.
Tag: GST
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) Cardiac phospholamban, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP9335.
Bioactivity Data: Untested
Full Length? Full Length
Expression Region: Met1 – Leu52
Amino Acid Sequence: MEKVQYLTRS AIRRASTIEM PQQARQKLQN LFINFCLILI CLLLICIIVM LL
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human Cardiac phospholamban Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human Cardiac phospholamban Protein General Information | |
|---|---|
| Alternate Names | |
| PLB; CMD1P; CMH18 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | P26678 |
| Entrez Gene ID | 5350 |
| Ensemble Gene ID | ENSG00000198523 |
| RefSeq Protein Accession(s) | NP_002658.1 |
| RefSeq mRNA Accession(s) | NM_002667.4 |
| UniProt ID(s) | P26678 |
| UniGene ID(s) | Hs.170839 |
| HGNC ID(s) | HGNC:9080 |
| KEGG Gene ID(s) | hsa:5350 |
| PharmGKB ID(s) | PA272 |
| General Description of Recombinant Human Cardiac phospholamban Protein. | |
| Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca2+. Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN. ATP2A2 inhibition is alleviated by PLN phosphorylation | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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