PDF DatasheetHuman Protein phosphatase 1 regulatory subunit 15A Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant Protein phosphatase 1 regulatory subunit 15A based upon sequence from: Human
Host: QP9341 protein expressed in Yeast.
Tag: His
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) Protein phosphatase 1 regulatory subunit 15A, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP9341.
Bioactivity Data: Untested
Full Length? Partial (see sequence information for more details).
Expression Region: Gly40 – Gly674
Amino Acid Sequence: GPLEPWLVEA VKGAALVEAG LEGEARTPLA IPHTPWGRRP EEEAEDSGGP GEDRETLGLK TSSSLPEAWG LLDDDDGMYG EREATSVPRG QGSQFADGQR APLSPSLLIR TLQGSDKNPG EEKAEEEGVA EEEGVNKFSY PPSHRECCPA VEEEDDEEAV KKEAHRTSTS ALSPGSKPST WVSCPGEEEN QATEDKRTER SKGARKTSVS PRSSGSDPRS WEYRSGEASE EKEEKAHKET GKGEAAPGPQ SSAPAQRPQL KSWWCQPSDE EEGEVKALGA AEKDGEAECP PCIPPPSAFL KAWVYWPGED TEEEEDEEED EDSDSGSDEE EGEAEASSST PATGVFLKSW VYQPGEDTEE EEDEDSDTGS AEDEREAETS ASTPPASAFL KAWVYRPGED TEEEEDEDVD SEDKEDDSEA ALGEAESDPH PSHPDQRAHF RGWGYRPGKE TEEEEAAEDW GEAEPCPFRV AIYVPGEKPP PPWAPPRLPL RLQRRLKRPE TPTHDPDPET PLKARKVRFS EKVTVHFLAV WAGPAQAARQ GPWEQLARDR SRFARRITQA QEELSPCLTP AARARAWARL RNPPLAPIPA LTQTLPSSSV PSSPVQTTPL SMS-QAVATP SRSSAAAAAA LDLSGRRG
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human Protein phosphatase 1 regulatory subunit 15A Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human Protein phosphatase 1 regulatory subunit 15A Protein General Information | |
|---|---|
| Alternate Names | |
| GADD34 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | PPP1R15A |
| Entrez Gene ID | 23645 |
| Ensemble Gene ID | ENSG00000087074 |
| RefSeq Protein Accession(s) | NP_055145.3 |
| RefSeq mRNA Accession(s) | NM_014330.3 |
| UniProt ID(s) | O75807 |
| UniGene ID(s) | Hs.631593 |
| HGNC ID(s) | HGNC:14375 |
| COSMIC ID Link(s) | PPP1R15A |
| KEGG Gene ID(s) | hsa:23645 |
| PharmGKB ID(s) | PA33632 |
| General Description of Recombinant Human Protein phosphatase 1 regulatory subunit 15A Protein. | |
| Recruits the serine/threonine-protein phosphatase PP1 to dephosphorylate the translation initiation factor eIF-2A/EIF2S1, thereby reversing the shut-off of protein synthesis initiated by stress-inducible kinases and facilitating recovery of cells from stress. Down-regulates the TGF-beta signaling pathway by promoting dephosphorylation of TGFB1 by PP1. May promote apoptosis by inducing TP53 phosphorylation on ‘Ser-15’. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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