PDF DatasheetHuman RING finger protein 11 Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant RING finger protein 11 based upon sequence from: Human
Host: QP9370 protein expressed in Yeast.
Tag: His
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) RING finger protein 11, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP9370.
Bioactivity Data: Untested
Full Length? Full Length
Expression Region: Gly2 – Asn154
Amino Acid Sequence: GNCLKSPTSD DISLLHESQS DRASFGEGTE PDQEPPPPYQ EQVPVPVYHP TPSQTRLATQ LTEEEQIRIA QRIGLIQHLP KGVYDPGRDG SEKKIRECVI CMMDFVYGDP IRFLPCMHIY HLDCIDDWLM RSFTCPSCME PVDAALLSSY ETN
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human RING finger protein 11 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human RING finger protein 11 Protein General Information | |
|---|---|
| Alternate Names | |
| SID1669; CGI-123 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | RNF11 |
| Entrez Gene ID | 26994 |
| Ensemble Gene ID | ENSG00000123091 |
| RefSeq Protein Accession(s) | NP_055187.1 |
| RefSeq mRNA Accession(s) | NM_014372.4 |
| UniProt ID(s) | Q9Y3C5 |
| UniGene ID(s) | Hs.309641 |
| HGNC ID(s) | HGNC:10056 |
| COSMIC ID Link(s) | RNF11 |
| KEGG Gene ID(s) | hsa:26994 |
| PharmGKB ID(s) | PA34420 |
| General Description of Recombinant Human RING finger protein 11 Protein. | |
| Essential component of a ubiquitin-editing protein complex, comprising also TNFAIP3, ITCH and TAX1BP1, that ensures the transient nature of inflammatory signaling pathways. Promotes the association of TNFAIP3 to RIPK1 after TNF stimulation. TNFAIP3 deubiquitinates ‘Lys-63’ polyubiquitin chains on RIPK1 and catalyzes the formation of ‘Lys-48’-polyubiquitin chains. This leads to RIPK1 proteasomal degradation and consequently termination of the TNF- or LPS-mediated activation of NF-kappa-B. Recruits STAMBP to the E3 ubiquitin-ligase SMURF2 for ubiquitination, leading to its degradation by the 26S proteasome. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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