PDF DatasheetHuman Transmembrane protease serine 2 Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant Transmembrane protease serine 2 based upon sequence from: Human
Host: QP9439 protein expressed in Yeast.
Tag: His
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) Transmembrane protease serine 2, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP9439.
Bioactivity Data: Untested
Full Length? Extracellular Domain
Expression Region: Trp106 – Gly492
Amino Acid Sequence: WKFMGSKCSN SGIECDSSGT CINPSNWCDG VSHCPGGEDE NRCVRLYGPN FILQVYSSQR KSWHPVCQDD WNENYGRAAC RDMGYKNNFY SSQGIVDDSG STSFMKLNTS AGNVDIYKKL YHSDACSSKA VVSLRCIACG VNLNSSRQSR IVGGESALPG AWPWQVSLHV QNVHVCGGSI ITPEWIVTAA HCVEKPLNNP WHWTAFAGIL RQSFMFYGAG YQVEKVISHP NYDSKTKNND IALMKLQKPL TFNDLVKPVC LPNPGMMLQP EQLCWISGWG ATEEKGKTSE VLNAAKVLLI ETQRCNSRYV YDNLITPAMI CAGFLQGNVD SCQGDSGGPL VTSKNNIWWL IGDTSWGSGC AKAYRPGVYG NVMVFTDWIY RQMRADG
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human Transmembrane protease serine 2 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human Transmembrane protease serine 2 Protein General Information | |
|---|---|
| Alternate Names | |
| PP9284; PRSS10 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | TMPRSS2 |
| Entrez Gene ID | 7113 |
| Ensemble Gene ID | ENSG00000184012 |
| RefSeq Protein Accession(s) | NP_001128571.1 |
| RefSeq mRNA Accession(s) | NM_001135099.1, NM_005656.3, XM_011529731.2 |
| UniProt ID(s) | O15393 |
| UniGene ID(s) | Hs.439309 |
| HGNC ID(s) | HGNC:11876 |
| COSMIC ID Link(s) | TMPRSS2 |
| KEGG Gene ID(s) | hsa:7113 |
| PharmGKB ID(s) | PA36577 |
| General Description of Recombinant Human Transmembrane protease serine 2 Protein. | |
| Serine protease that proteolytically cleaves and activates the viral spike glycoproteins which facilitate virus-cell membrane fusions; spike proteins are synthesized and maintained in precursor intermediate folding states and proteolysis permits the refolding and energy release required to create stable virus-cell linkages and membrane coalescence. Facilitates human SARS coronavirus (SARS-CoV) infection via two independent mechanisms, proteolytic cleavage of ACE2, which might promote viral uptake, and cleavage of coronavirus spike glycoprotein which activates the glycoprotein for cathepsin L-independent host cell entry. Proteolytically cleaves and activates the spike glycoproteins of human coronavirus 229E (HCoV-229E) and human coronavirus EMC (HCoV-EMC) and the fusion glycoproteins F0 of Sendai virus (SeV), human metapneumovirus (HMPV), human parainfluenza 1, 2, 3, 4a and 4b viruses (HPIV). Essential for spread and pathogenesis of influenza A virus (strains H1N1, H3N2 and H7N9); involved in proteolytic cleavage and activation of hemagglutinin (HA) protein which is essential for viral infectivity. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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