PDF DatasheetHuman UDP-glucuronosyltransferase 1-1 Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant UDP-glucuronosyltransferase 1-1 based upon sequence from: Human
Host: QP9458 protein expressed in Yeast.
Tag: His
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) UDP-glucuronosyltransferase 1-1, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP9458.
Bioactivity Data: Untested
Full Length? Full Length
Expression Region: His26 – His533
Amino Acid Sequence: HAGKILLIPV DGSHWLSMLG AIQQLQQRGH EIVVLAPDAS LYIRDGAFYT LKTYPVPFQR EDVKESFVSL GHNVFENDSF LQRVIKTYKK IKKDSAMLLS GCSHLLHNKE LMASLAESSF DVMLTDPFLP CSPIVAQYLS LPTVFFLHAL PCSLEFEATQ CPNPFSYVPR PLSSHSDHMT FLQRVKNMLI AFSQNFLCDV VYSPYATLAS EFLQREVTVQ DLLSSASVWL FRSDFVKDYP RPIMPNMVFV GGINCLHQNP LSQEFEAYIN ASGEHGIVVF SLGSMVSEIP EKKAMAIADA LGKIPQTVLW RYTGTRPSNL ANNTILVKWL PQNDLLGHPM TRAFITHAGS HGVYESICNG VPMVMMPLFG DQMDNAKRME TKGAGVTLNV LEMTSEDLEN ALKAVINDKS YKENIMRLSS LHKDRPVEPL DLAVFWVEFV MRHKGAPHLR PAAHDLTWYQ YHSLDVIGFL LAVVLTVAFI TFKCCAYGYR KCLGKKGRVK KAHKSKTH
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human UDP-glucuronosyltransferase 1-1 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human UDP-glucuronosyltransferase 1-1 Protein General Information | |
|---|---|
| Alternate Names | |
| UDPGT; UDPGT 1-1; BILIQTL1; UGT1A; HUG-BR1; UGT1; GNT1 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | UGT1A1 |
| Entrez Gene ID | 54658 |
| Ensemble Gene ID | ENSG00000241635 |
| RefSeq Protein Accession(s) | NP_000454.1 |
| RefSeq mRNA Accession(s) | NM_000463.2 |
| UniProt ID(s) | P22309 |
| UniGene ID(s) | Hs.554822 |
| HGNC ID(s) | HGNC:12530 |
| COSMIC ID Link(s) | UGT1A1 |
| KEGG Gene ID(s) | hsa:54658 |
| PharmGKB ID(s) | PA37181 |
| General Description of Recombinant Human UDP-glucuronosyltransferase 1-1 Protein. | |
| UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform glucuronidates bilirubin IX-alpha to form both the IX-alpha-C8 and IX-alpha-C12 monoconjugates and diconjugate. Is also able to catalyze the glucuronidation of 17beta-estradiol, 17alpha-ethinylestradiol, 1-hydroxypyrene, 4-methylumbelliferone, 1-naphthol, paranitrophenol, scopoletin, and umbelliferone. Isoform 2 lacks transferase activity but acts as a negative regulator of isoform 1. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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