PDF DatasheetMouse Uromodulin Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant Uromodulin based upon sequence from: Mouse
Host: QP9459 protein expressed in Yeast.
Tag: His
Protein Construction: A DNA sequence encoding the Mus musculus (Mouse) Uromodulin, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP9459.
Bioactivity Data: Untested
Full Length? Partial (see sequence information for more details).
Expression Region: Asn25 – Phe588
Amino Acid Sequence: NSTEARRCSE CHNNATCTVD GVVTTCSCQT GFTGDGLVCE DMDECATPWT HNCSNSSCVN TPGSFKCSCQ DGFRLTPELS CTDVDECSEQ GLSNCHALAT CVNTEGDYLC VCPEGFTGDG WYCECSPGSC EPGLDCLPQG PDGKLVCQDP CNTYETLTEY WRSTEYGVGY SCDAGLHGWY RFTGQGGVRM AETCVPVLRC NTAAPMWLNG SHPSSSEGIV SRTACAHWSD QCCRWSTEIQ VKACPGGFYI YNLTAPPECN LAYCTDPSSV EGTCEECRVD EDCISDNGRW RCQCKQDSNI TDVSQLEYRL ECGANDIKMS LRKCQLQSLG FMNVFMYLND RQCSGFSESD ERDWMSIVTP ARNGPCGTVL RRNETHATYS NTLYLANAII IRDIIIRMNF ECSYPLDMKV SLKTSLQPMV SALNISLGGT GKFTVRMALF QSPTYTQPHQ GPSVMLSTEA FLYVGTMLDG GDLSRFVLLM TNCYATPSSN STDPVKYFII QDSCPRTEDT TIQVTENGES SQARFSVQMF RFAGNYDLVY LHCEVYLCDS TSEQCKPTCS GTRF
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Mouse Uromodulin Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Mouse Uromodulin Protein General Information | |
|---|---|
| Alternate Names | |
| Urehd1; THP; urehr4 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | Umod |
| Entrez Gene ID | 22242 |
| Ensemble Gene ID | ENSMUSG00000030963 |
| RefSeq Protein Accession(s) | NP_001265534.1 |
| RefSeq mRNA Accession(s) | NM_001278605.1, NM_009470.5 |
| UniProt ID(s) | Q91X17 |
| UniGene ID(s) | Mm.10826 |
| COSMIC ID Link(s) | Umod |
| KEGG Gene ID(s) | mmu:22242 |
| General Description of Recombinant Mouse Uromodulin Protein. | |
| Uromodulin: Functions in biogenesis and organization of the apical membrane of epithelial cells of the thick ascending limb of Henle’s loop (TALH), where it promotes formation of complex filamentous gel-like structure that may play a role in the water barrier permeability. May serve as a receptor for binding and endocytosis of cytokines (IL-1, IL-2) and TNF. Facilitates neutrophil migration across renal epithelia.By similarity Uromodulin, secreted form: In the urine, may contribute to colloid osmotic pressure, retards passage of positively charged electrolytes, prevents urinary tract infection and inhibits formation of liquid containing supersaturated salts and subsequent formation of salt crystals. |
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Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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