PDF DatasheetHuman Transcriptional coactivator YAP1 Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant Transcriptional coactivator YAP1 based upon sequence from: Human
Host: QP9470 protein expressed in Yeast.
Tag: His
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) Transcriptional coactivator YAP1, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP9470.
Bioactivity Data: Untested
Full Length? Full Length
Expression Region: Met1 – Leu504
Amino Acid Sequence: MDPGQQPPPQ PAPQGQGQPP SQPPQGQGPP SGPGQPAPAA TQAAPQAPPA GHQIVHVRGD SETDLEALFN AVMNPKTANV PQTVPMRLRK LPDSFFKPPE PKSHSRQAST DAGTAGALTP QHVRAHSSPA SLQLGAVSPG TLTPTGVVSG PAATPTAQHL RQSSFEIPDD VPLPAGWEMA KTSSGQRYFL NHIDQTTTWQ DPRKAMLSQM NVTAPTSPPV QQNMMNSASG PLPDGWEQAM TQDGEIYYIN HKNKTTSWLD PRLDPRFAMN QRISQSAPVK QPPPLAPQSP QGGVMGGSNS NQQQQMRLQQ LQMEKERLRL KQQELLRQAM RNINPSTANS PKCQELALRS QLPTLEQDGG TQNPVSSPGM SQELRTMTTN SSDPFLNSGT YHSRDESTDS GLSMSSYSVP RTPDDFLNSV DEMDTGDTIN QSTLPSQQNR FPDYLEAIPG TNVDLGTLEG DGMNIEGEEL MPSLQEALSS DILNDMESVL AATKLDKESF LTWL
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human Transcriptional coactivator YAP1 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human Transcriptional coactivator YAP1 Protein General Information | |
|---|---|
| Alternate Names | |
| YKI; COB1; YAP; YAP2; YAP65 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | YAP1 |
| Entrez Gene ID | 10413 |
| Ensemble Gene ID | ENSG00000137693 |
| RefSeq Protein Accession(s) | NP_001123617.1 |
| RefSeq mRNA Accession(s) | NM_001130145.2, NM_001195044.1, NM_001195045.1, NM_001282097.1, NM_001282098.1, NM_001282099.1, NM_001282100.1, NM_001282101.1 |
| UniProt ID(s) | P46937 |
| UniGene ID(s) | Hs.503692 |
| HGNC ID(s) | HGNC:16262 |
| COSMIC ID Link(s) | YAP1 |
| KEGG Gene ID(s) | hsa:10413 |
| PharmGKB ID(s) | PA38103 |
| General Description of Recombinant Human Transcriptional coactivator YAP1 Protein. | |
| Transcriptional regulator which can act both as a coactivator and a corepressor and is the critical downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Plays a key role to control cell proliferation in response to cell contact. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. The presence of TEAD transcription factors are required for it to stimulate gene expression, cell growth, anchorage-independent growth, and epithelial mesenchymal transition (T) induction. Isoform 2 and isoform 3 can activate the C-terminal fragment (CTF) of ERBB4 (isoform 3). | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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