PDF DatasheetMouse Nuclease-sensitive element-binding protein 1 Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant Nuclease-sensitive element-binding protein 1 based upon sequence from: Mouse
Host: QP9471 protein expressed in Yeast.
Tag: His
Protein Construction: A DNA sequence encoding the Mus musculus (Mouse) Nuclease-sensitive element-binding protein 1, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP9471.
Bioactivity Data: Untested
Full Length? Full Length
Expression Region: Ser2 – Glu322
Amino Acid Sequence: SSEAETQQPP AAPAAALSAA DTKPGSTGSG AGSGGPGGLT SAAPAGGDKK VIATKVLGTV KWFNVRNGYG FINRNDTKED VFVHQTAIKK NNPRKYLRSV GDGETVEFDV VEGEKGAEAA NVTGPGGVPV QGSKYAADRN HYRRYPRRRG PPRNYQQNYQ NSESGEKNEG SESAPEGQAQ QRRPYRRRRF PPYYMRRPYA RRPQYSNPPV QGEVMEGADN QGAGEQGRPV RQNMYRGYRP RFRRGPPRQR QPREDGNEED KENQGDETQG QQPPQRRYRR NFNYRRRRPE NPKPQDGKET KAADPPAENS SAPEAEQGGA E
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Mouse Nuclease-sensitive element-binding protein 1 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Mouse Nuclease-sensitive element-binding protein 1 Protein General Information | |
|---|---|
| Alternate Names | |
| YB-1; mYB-1a; Nsep1; dbpB; 1700102N10Rik; C79409; EF1A; MSY1 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | Ybx1 |
| Entrez Gene ID | 22608 |
| Ensemble Gene ID | ENSMUSG00000028639 |
| RefSeq Protein Accession(s) | NP_035862.2 |
| RefSeq mRNA Accession(s) | NM_011732.2 |
| UniProt ID(s) | P62960 |
| UniGene ID(s) | Mm.258204 |
| COSMIC ID Link(s) | Ybx1 |
| KEGG Gene ID(s) | mmu:22608 |
| General Description of Recombinant Mouse Nuclease-sensitive element-binding protein 1 Protein. | |
| Mediates pre-mRNA alternative splicing regulation. Component of the CRD-mediated complex that promotes MYC mRNA stability. Binds to splice sites in pre-mRNA and regulates splice site selection. Binds and stabilizes Cytoplasmic domain mRNA. Contributes to the regulation of translation by modulating the interaction between the mRNA and eukaryotic initiation factors. Binds to promoters that contain a Y-box (5′-CTGATTGGCCAA-3′), such as HLA class II genes. Regulates the transcription of numerous genes. Promotes separation of DNA strands that contain mismatches or are modified by cisplatin. Has endonucleolytic activity and can introduce nicks or breaks into double-stranded DNA (in vitro). May play a role in DNA repair. Its transcriptional activity on the multidrug resistance gene MDR1 is enhanced in presence of the APEX1 acetylated form at ‘Lys-6’ and ‘Lys-7’. Binds preferentially to 5′-[CU]CUGCG-3′ motif in vitro .The secreted form acts as an Extracellular domain mitogen and stimulates cell migration and proliferation. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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