PDF Datasheethepatitis Capsid protein Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant Capsid protein based upon sequence from: hepatitis
Host: QP9509 protein expressed in Yeast.
Tag: His
Protein Construction: A DNA sequence encoding the Hepatitis B virus genotype C subtype ayw (isolate China/Tibet127/2002) (HBV-C) Capsid protein, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP9509.
Bioactivity Data: Untested
Full Length? Full Length
Expression Region: Met1 – Cys183
Amino Acid Sequence: MDIDPYKEFG ASVEVLSFLP SDFFPSNRDL LDTASALDRE ALESPEHCSP HHTALRQAIL CWGELMNLAT WVGSNLEDPA SRELVVSYVN VNMGLKIRQL LWFHISCLTF GRETVLEYLV SFGVWIRTPP AYRPPNAPIL STLPETTVVR RRGRSPRRRT PSPRRRRSQS PRRRRSQSRE SQC
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of hepatitis Capsid protein Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant hepatitis Capsid protein Protein General Information | |
|---|---|
| Curated Database and Bioinformatic Data | |
| Gene Symbol | C |
| UniProt ID(s) | P0C6H7 |
| General Description of Recombinant hepatitis Capsid protein Protein. | |
| Self assbles to form an icosahedral capsid. Most capsid appear to be large particles with a icosahedral symmetry of T=4 and consist of 240 copies of capsid protein, though a fraction forms smaller T=3 particles consisting of 180 capsid proteins. Entering capsid are transported along microtubules to the nucleus. Phosphorylation of the capsid is thought to induce exposure of nuclear localization signal in the C-terminal portion of the capsid protein that allows binding to the nuclear pore complex via the importin (karyopherin-) alpha and beta. Capsids are imported in intact form through the nuclear pore into the nuclear basket, where it probably binds NUP153. Only capsids that contain the mature viral genome can release the viral DNA and capsid protein into the nucleoplasm. Immature capsids get stucked in the basket. Capsids encapsulate the pre-genomic RNA and the P protein. Pre-genomic RNA is reverse transcribed into DNA while the capsid is still in the cytoplasm. The capsid can then either be directed to the nucleus, providing more genome for transcription, or bud through the endoplasmic reticulum to provide new virions .Encapsidates hepatitis delta genome. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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