PDF DatasheetC. botulinum Botulinum neurotoxin type B Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant Botulinum neurotoxin type B based upon sequence from: C. botulinum
Host: QP9517 protein expressed in Yeast.
Tag: His
Protein Construction: A DNA sequence encoding the Clostridium botulinum Botulinum neurotoxin type B, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP9517.
Bioactivity Data: Untested
Full Length? Partial (see sequence information for more details).
Expression Region: Met1 – Glu427
Amino Acid Sequence: MPVTINNFNY NDPIDNNNII MMEPPFARGT GRYYKAFKIT DRIWIIPERY TFGYKPEDFN KSSGIFNRDV CEYYDPDYLN TNDKKNIFLQ TMIKLFNRIK SKPLGEKLLE MIINGIPYLG DRRVPLEEFN TNIASVTVNK LISNPGEVER KKGIFANLII FGPGPVLNEN ETIDIGIQNH FASREGFGGI MQMKFCPEYV SVFNNVQENK GASIFNRRGY FSDPALILMH ELIHVLHGLY GIKVDDLPIV PNEKKFFMQS TDAIQAEELY TFGGQDPSII TPSTDKSIYD KVLQNFRGIV DRLNKVLVCI SDPNININIY KNKFKDKYKF VEDSEGKYSI DVESFDKLYK SLMFGFTETN IAENYKIKTR ASYFSDSLPP VKIKNLLDNE IYTIEEGFNI SDKDMEKEYR GQNKAINKQA YEEISKE
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of C. botulinum Botulinum neurotoxin type B Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant C. botulinum Botulinum neurotoxin type B Protein General Information | |
|---|---|
| Curated Database and Bioinformatic Data | |
| Gene Symbol | botB |
| UniProt ID(s) | P10844 |
| General Description of Recombinant C. botulinum Botulinum neurotoxin type B Protein. | |
| Botulinum toxin acts by inhibiting neurotransmitter release. It binds to peripheral neuronal synapses, is internalized and moves by retrograde transport up the axon into the spinal cord where it can move between postsynaptic and presynaptic neurons. It inhibits neurotransmitter release by acting as a zinc endopeptidase that cleaves the ’76-Gln-|-Phe-77′ bond of synaptobrevin-2. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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