PDF DatasheetE. coli Transcriptional regulatory protein PhoP Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant Transcriptional regulatory protein PhoP based upon sequence from: E. coli
Host: QP9558 protein expressed in Yeast.
Tag: His-Myc
Protein Construction: A DNA sequence encoding the Escherichia coli (strain K12) Transcriptional regulatory protein PhoP, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP9558.
Bioactivity Data: Untested
Full Length? Full Length
Expression Region: Met1 – Arg223
Amino Acid Sequence: MRVLVVEDNA LLRHHLKVQI QDAGHQVDDA EDAKEADYYL NEHIPDIAIV DLGLPDEDGL SLIRRWRSND VSLPILVLTA RESWQDKVEV LSAGADDYVT KPFHIEEVMA RMQALMRRNS GLASQVISLP PFQVDLSRRE LSINDEVIKL TAFEYTIMET LIRNNGKVVS KDSLMLQLYP DAELRESHTI DVLMGRLRKK IQAQYPQEVI TTVRGQGYLF ELR
Purity: Greater than 80% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of E. coli Transcriptional regulatory protein PhoP Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant E. coli Transcriptional regulatory protein PhoP Protein General Information | |
|---|---|
| Alternate Names | |
| b1130; JW1116; ECK1116 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | phoP |
| Entrez Gene ID | 945697 |
| RefSeq Protein Accession(s) | NP_415648.1 |
| RefSeq mRNA Accession(s) | NC_000913.3, NZ_LN832404.1 |
| UniProt ID(s) | P23836 |
| KEGG Gene ID(s) | ecj:JW1116 |
| General Description of Recombinant E. coli Transcriptional regulatory protein PhoP Protein. | |
| Member of the two-component regulatory system PhoP/PhoQ involved in adaptation to low Mg2+ environments and the control of acid resistance genes. In low periplasmic Mg2+, PhoQ phosphorylates PhoP, resulting in the expression of PhoP-activated genes (PAG) and repression of PhoP-repressed genes (PRG). In high periplasmic Mg2+, PhoQ dephosphorylates phospho-PhoP, resulting in the repression of PAG and may lead to expression of some PRG. Mediates magnesium influx to the cytosol by activation of MgtA. Promotes expression of the two-component regulatory system rstA/rstB and transcription of the hemL, mgrB, nagA, slyB, vboR and yrbL genes. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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