PDF Datasheethepatitis Large envelope protein Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant Large envelope protein based upon sequence from: hepatitis
Host: QP9585 protein expressed in Yeast.
Tag: His
Protein Construction: A DNA sequence encoding the Hepatitis B virus genotype C subtype adr (isolate Japan/Nishioka/1983) (HBV-C) Large envelope protein, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP9585.
Bioactivity Data: Untested
Full Length? Partial (see sequence information for more details).
Expression Region: Gly2 – Gly181
Amino Acid Sequence: GGWSSKPRQG MGTNLSVPNP LGFFPDHQLD PAFGANSNNP DWDFNPNKDH WPEANQVGVG TFGPGFTPPH GGLLGWSPQA QGILTTVPAA PPPASTNRQS GRQPTPISPP LRDSHPQAMQ WNSTTFHQAL LDPRVRGLYF PAGGSSSGTV NPVPTTASPI SSIFSRTGDP APNMENTTSG
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of hepatitis Large envelope protein Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant hepatitis Large envelope protein Protein General Information | |
|---|---|
| Curated Database and Bioinformatic Data | |
| Gene Symbol | S |
| UniProt ID(s) | P31868 |
| General Description of Recombinant hepatitis Large envelope protein Protein. | |
| The large envelope protein exists in two topological conformations, one which is termed ‘external’ or Le-HBsAg and the other ‘internal’ or Li-HBsAg. In its external conformation the protein attaches the virus to cell receptors and thereby initiating infection. This interaction determines the species specificity and liver tropism. This attachment induces virion internalization predominantly through caveolin-mediated endocytosis. The large envelope protein also assumes fusion between virion membrane and endosomal membrane (Probable). In its internal conformation the protein plays a role in virion morphogenesis and mediates the contact with the nucleocapsid like a matrix protein (By similarity). | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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