PDF DatasheetInfluenza Hemagglutinin-esterase-fusion glycoprotein Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant Hemagglutinin-esterase-fusion glycoprotein based upon sequence from: Influenza
Host: QP9694 protein expressed in Yeast.
Tag: His
Protein Construction: A DNA sequence encoding the Influenza C virus (strain C/California/1978) Hemagglutinin-esterase-fusion glycoprotein, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP9694.
Bioactivity Data: Untested
Full Length? Extracellular Domain
Expression Region: Glu15 – Ser629
Amino Acid Sequence: EKIKICLQKQ VNSSFSLHNG FGGNLYATEE KRMFELVKPK AGASVLNQST WIGFGDSRTD QSNSAFPRSL MSAKTADKFR SLSGGSLMLS MFGPPGKVDY LYQGCGKHKV FYEGVNWSPH AAIDCYRKNW TDIKLNFQKS IYELASQSHC MSLVNALDKT IPLQVTKGVA KNCNNSFLKN PALYTQEVKP LEQICGEENL AFFTLPTQFG TYECKLHLVA SCYFIYDSKE VYNKRGCGNY FQVIYDSSGK VVGGLDNRVS PYTGNSGDTP TMQCDMLQLK PGRYSVRSSP RFLLMPERSY CFDMKEKGPV TAVQSIWGKG RKSDYAVDQA CLSTPGCMLI QKQKPYIGEA DDHHGDQEMR ELLSGLDYEA RCISQSGWVN ETSPFTEEYL LPPKFGRCPL AAKEESIPKI PDGLLIPTSG TDTTVTKPKS RIFGIDDLII GLLFVAIVEA GIGGYLLGSR KESGGGVTKE SAEKGFEKIG NDIQILRSST NIAIEKLNDR ISHDEQAIRD LTLEIENARS EALLGELGII RALLVGNISI GLQESLWELA SEITNRAGDL AVEVSPGCWI IDNNICDQSC QNFIFKFNET APVPTIPPLD TKIDLQSDPF YWGSS
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Influenza Hemagglutinin-esterase-fusion glycoprotein Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Influenza Hemagglutinin-esterase-fusion glycoprotein Protein General Information | |
|---|---|
| Curated Database and Bioinformatic Data | |
| Gene Symbol | HE |
| UniProt ID(s) | P03465 |
| General Description of Recombinant Influenza Hemagglutinin-esterase-fusion glycoprotein Protein. | |
| Binds to the N-acetyl-9-O-acetylneuraminic acid residues on the cell surface, bringing about the attachment of the virus particle to the cell. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the mbrane of the endocytosed virus particle with the endosomal mbrane. Low pH in endosomes induce an irreversible conformational change in HEF2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore. Displays a receptor-destroying activity which is a neuraminidate-O-acetyl esterase. This activity cleaves off any receptor on the cell surface, which would otherwise prevent virions release. These cleavages prevent self-aggregation and ensure the efficient spread of the progeny virus from cell to cell . | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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