PDF DatasheetHuman Fusion glycoprotein F0 Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant Fusion glycoprotein F0 based upon sequence from: Human
Host: QP9719 protein expressed in Yeast.
Tag: His
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) Fusion glycoprotein F0, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP9719.
Bioactivity Data: Untested
Full Length? Partial (see sequence information for more details).
Expression Region: Phe137 – Lys574
Amino Acid Sequence: FLGFLLGVGS AIASGIAVSK VLHLEGEVNK IKNALLSTNK AVVSLSNGVS VLTSKVLDLK NYINNQLLPI VNQQSCRISN IETVIEFQQK NSRLLEINRE FSVNAGVTTP LSTYMLTNSE LLSLINDMPI TNDQKKLMSS NVQIVRQQSY SIMSIIKEEV LAYVVQLPIY GVIDTPCWKL HTSPLCTTNI KEGSNICLTR TDRGWYCDNA GSVSFFPQAD TCKVQSNRVF CDTMNSLTLP SEVSLCNTDI FNSKYDCKIM TSKTDISSSV ITSLGAIVSC YGKTKCTASN KNRGIIKTFS NGCDYVSNKG VDTVSVGNTL YYVNKLEGKN LYVKGEPIIN YYDPLVFPSD EFDASISQVN EKINQSLAFI RRSDELLHNV NTGKSTTNIM ITTIIIVIIV VLLSLIAIGL LLYCKAKNTP VTLSKDQLSG INNIAFSK
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human Fusion glycoprotein F0 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human Fusion glycoprotein F0 Protein (137-574aa) General Information | |
|---|---|
| Alternate Names | |
| HRSVgp08 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | F |
| Entrez Gene ID | 1489825 |
| RefSeq Protein Accession(s) | NP_056863.1 |
| RefSeq mRNA Accession(s) | NC_001781.1 |
| UniProt ID(s) | O36634 |
| KEGG Gene ID(s) | vg:1489825 |
| General Description of Recombinant Human Fusion glycoprotein F0 Protein (137-574aa). | |
| During virus entry, induces fusion of viral and cellular mbranes leading to delivery of the nucleocapsid into the cytoplasm. The fusogenic activity is inactive untill entry into host cell endosome, where a furin-like protease cleaves off a small peptide between F1 and F2. Interacts directly with heparan sulfate and may participates in virus attachment. Furthermore, the F2 subunit was identifed as the major determinant of RSV host cell specificity. Later in infection, proteins F expressed at the plasma mbrane of infected cells can mediate fusion with adjacent cells to form syncytia, a cytopathic effect that could lead to tissue necrosis. The fusion protein is also able to trigger p53-dependent apoptosis. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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