PDF DatasheetHuman ACVR2B Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant ACVR2B based upon sequence from: Human
Host: QP9768 protein expressed in Yeast.
Tag: His
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) ACVR2B, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP9768.
Bioactivity Data: Untested
Full Length? Extracellular Domain
Expression Region: Ser19 – Thr137
Amino Acid Sequence: SGRGEAETRE CIYYNANWEL ERTNQSGLER CEGEQDKRLH CYASWRNSSG TIELVKKGCW LDDFNCYDRQ ECVATEENPQ VYFCCCEGNF CNERFTHLPE AGGPEVTYEP PPTAPTLLT
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human ACVR2B Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human ACVR2B Protein General Information | |
|---|---|
| Alternate Names | |
| ACVR2B; ACTRIIB; HTX4; ActR-IIB | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | ACVR2B |
| Entrez Gene ID | 93 |
| Ensemble Gene ID | ENSG00000114739 |
| RefSeq Protein Accession(s) | NP_001097.2 |
| RefSeq mRNA Accession(s) | NM_001106.3 |
| UniProt ID(s) | Q13705 |
| UniGene ID(s) | Hs.174273 |
| HGNC ID(s) | HGNC:174 |
| COSMIC ID Link(s) | ACVR2B |
| KEGG Gene ID(s) | hsa:93 |
| PharmGKB ID(s) | PA24495 |
| General Description of Recombinant Human ACVR2B Protein. | |
| Transmembrane serine/threonine kinase activin type-2 receptor forming an activin receptor complex with activin type-1 serine/threonine kinase receptors (ACVR1, ACVR1B or ACVR1c). Transduces the activin signal from the cell surface to the cytoplasm and is thus regulating many physiological and pathological processes including neuronal differentiation and neuronal survival, hair follicle development and cycling, FSH production by the pituitary gland, wound healing, Extracellular domain matrix production, immunosuppression and carcinogenesis. Activin is also thought to have a paracrine or autocrine role in follicular development in the ovary. Within the receptor complex, the type-2 receptors act as a primary activin receptors (binds activin-A/INHBA, activin-B/INHBB as well as inhibin-A/INHA-INHBA). The type-1 receptors like ACVR1B act as downstream transducers of activin signals. Activin binds to type-2 receptor at the plasma membrane and activates its serine-threonine kinase. The activated receptor type-2 then phosphorylates and activates the type-1 receptor. Once activated, the type-1 receptor binds and phosphorylates the SMAD proteins SMAD2 and SMAD3, on serine residues of the C-terminal tail. Soon after their association with the activin receptor and subsequent phosphorylation, SMAD2 and SMAD3 are released into the cytoplasm where they interact with the common partner SMAD4. This SMAD complex translocates into the nucleus where it mediates activin-induced transcription. Inhibitory SMAD7, which is recruited to ACVR1B through FKBP1A, can prevent the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. Activin signal transduction is also antagonized by the binding to the receptor of inhibin-B via the IGSF1 inhibin coreceptor. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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