PDF DatasheetHuman BRCA1-associated protein Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant BRCA1-associated protein based upon sequence from Human
Host: QP9827 protein expressed in Yeast.
Tag: His
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) BRCA1-associated protein, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Recommended Applications: Immunogen, Protein Standard, Cell culture, or Other Cell Biology Applications.
Application Notes: Please contact us for application specific information for QP9827.
Bioactivity Data: Untested
Full Length? Full Length
Expression Region: Met1 – Lys592
Amino Acid Sequence: MSVSLVVIRL ELAEHSPVPA GFGFSAAAGE MSDEEIKKTT LASAVACLEG KSPGEKVAII HQHLGRREMT DVIIETMKSN PDELKTTVEE RKSSEASPTA QRSKDHSKEC INAAPDSPSK QLPDQISFFS GNPSVEIVHG IMHLYKTNKM TSLKEDVRRS AMLCILTVPA AMTSHDLMKF VAPFNEVIEQ MKIIRDSTPN QYMVLIKFRA QADADSFYMT CNGRQFNSIE DDVCQLVYVE RAEVLKSEDG ASLPVMDLTE LPKCTVCLER MDESVNGILT TLCNHSFHSQ CLQRWDDTTC PVCRYCQTPE PVEENKCFEC GVQENLWICL ICGHIGCGRY VSRHAYKHFE ETQHTYAMQL TNHRVWDYAG DNYVHRLVAS KTDGKIVQYE CEGDTCQEEK IDALQLEYSY LLTSQLESQR IYWENKIVRI EKDTAEEINN MKTKFKETIE KCDNLEHKLN DLLKEKQSVE RKCTQLNTKV AKLTNELKEE QEMNKCLRAN QVLLQNKLKE EERVLKETCD QKDLQITEIQ EQLRDVMFYL ETQQKINHLP AETRQEIQEG QINIAMASAS SPASSGGSGK LPSRKGRSKR GK
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions: Concentrated protein in liquid format. Reconstitution is not necessary.
Concentration of Human BRCA1-associated protein Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human BRCA1-associated protein Protein General Information | |
|---|---|
| Alternate Names | |
| BRAP2; RNF52; IMP | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | BRAP |
| Entrez Gene ID | 8315 |
| Ensemble Gene ID | ENSG00000089234 |
| RefSeq Protein Accession(s) | NP_006759.3 |
| RefSeq mRNA Accession(s) | NM_006768.4 |
| UniProt ID(s) | Q7Z569 |
| UniGene ID(s) | Hs.530940 |
| HGNC ID(s) | HGNC:1099 |
| COSMIC ID Link(s) | BRAP |
| KEGG Gene ID(s) | hsa:8315 |
| PharmGKB ID(s) | PA25410 |
| General Description of Recombinant Human BRCA1-associated protein Protein. | |
| Negatively regulates MAP kinase activation by limiting the formation of Raf/MEK complexes probably by inactivation of the KSR1 scaffold protein. Also acts as a Ras responsive E3 ubiquitin ligase that, on activation of Ras, is modified by auto-polyubiquitination resulting in the release of inhibition of Raf/MEK complex formation. May also act as a Cytoplasmic domain retention protein with a role in regulating nuclear transport. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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