PDF DatasheetMouse Kallikrein-14 Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant Kallikrein-14 based upon sequence from Mouse
Host: QP9831 protein expressed in Yeast.
Tag: His
Protein Construction: A DNA sequence encoding the Mus musculus (Mouse) Kallikrein-14, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Recommended Applications: Immunogen, Protein Standard, Cell culture, or Other Cell Biology Applications.
Application Notes: Please contact us for application specific information for QP9831.
Bioactivity Data: Untested
Full Length? Full Length of Mature Protein
Expression Region: Ile24 – Asn250
Amino Acid Sequence: IIGGYRCVRN SQPWQVALQA GPGHRFLCGG VLLSDQWVIT AAHCARPILH VALGKHNIRR WEATQQVVRV ARQVPHPQYQ PQAHDNDLML LKLQKKVRLG RAVKTISVAS SCASPGTPCR VSGWGTIASP IARYPTALQC VNVNIMSEQA CHRAYPGIIT SGMVCAGVPE GGKDSCQGDS GGPLVCGGQL QGLVSWGMER CAMPGYPGVY ANLCNYHSWI QRTMQSN
Purity: Greater than 84% as determined by SDS-PAGE.
Reconstitution Instructions: Concentrated protein in liquid format. Reconstitution is not necessary.
Concentration of Mouse Kallikrein-14 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Mouse Kallikrein-14 Protein General Information | |
|---|---|
| Alternate Names | |
| GK14 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | Klk14 |
| Entrez Gene ID | 317653 |
| Ensemble Gene ID | ENSMUSG00000044737 |
| RefSeq Protein Accession(s) | NP_777355.1 |
| RefSeq mRNA Accession(s) | NM_174866.3, XM_006540955.3 |
| UniProt ID(s) | Q8CGR5 |
| UniGene ID(s) | Mm.247377 |
| COSMIC ID Link(s) | Klk14 |
| KEGG Gene ID(s) | mmu:317653 |
| General Description of Recombinant Mouse Kallikrein-14 Protein. | |
| Serine-type endopeptidase with a dual trypsin-like and chymotrypsin-like substrate specificity. May activate/inactivate the proteinase-activated receptors F2R, F2RL1 and F2RL3 and other kallikreins including KLK1, KLK3, KLK5 and KLK11. May function in seminal clot liquefaction through direct cleavage of the semenogelin SEMG1 and SEMG2 and activation of KLK3. May function through desmoglein DSG1 cleavage in epidermal desquamation a process by which the most superficial corneocytes are shed from the skin surface. May be involved in several aspects of tumor progression including growth, invasion and angiogenesis Inhibited by SERPINA1, SERPINC1, SERPINE1, SERPINF2, aprotinin, soybean, trypsin inhibitor and leupeptin. Inhibited by serine protease inhibitor SPINK5. Has an autoproteolytic activity which may have a regulatory effect. Activated by citrate and inhibited by zinc and to a lower extent by manganese |
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Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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