Human Twinkle protein, mitochondrial Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant Twinkle protein, mitochondrial based upon sequence from Human
Host: QP9861 protein expressed in Yeast.
Tag: His
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) Twinkle protein, mitochondrial, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Recommended Applications: Immunogen, Protein Standard, Cell culture, or Other Cell Biology Applications.
Application Notes: Please contact us for application specific information for QP9861.
Bioactivity Data: Untested
Full Length? Full Length
Expression Region: Ala32 – Lys684
Amino Acid Sequence: APGPPRRRYR KETLQALDMP VLPVTATEIR QYLRGHGIPF QDGHSCLRAL SPFAESSQLK GQTGVTTSFS LFIDKTTGHF LCMTSLAEGS WEDFQASVEG RGDGAREGFL LSKAPEFEDS EEVRRIWNRA IPLWELPDQE EVQLADTMFG LTKVTDDTLK RFSVRYLRPA RSLVFPWFSP GGSGLRGLKL LEAKCQGDGV SYEETTIPRP SAYHNLFGLP LISRRDAEVV LTSRELDSLA LNQSTGLPTL TLPRGTTCLP PALLPYLEQF RRIVFWLGDD LRSWEAAKLF ARKLNPKRCF LVRPGDQQPR PLEALNGGFN LSRILRTALP AWHKSIVSFR QLREEVLGEL SNVEQAAGLR WSRFPDLNRI LKGHRKGELT VFTGPTGSGK TTFISEYALD LCSQGVNTLW GSFEISNVRL ARVMLTQFAE GRLEDQLDKY DHWADRFEDL PLYFMTFHGQ QSIRTVIDTM QHAVYVYDIC HVIIDNLQFM MGHEQLSTDR IAAQDYIIGV FRKFATDNNC HVTLVIHPRK EDDDKELQTA SIFGSAKASQ EADNVLILQD RKLVTGPGKR YLQVSKNRFD GDVGVFPLEF NKNSLTFSIP PKNKARLKKI KDDTGPVAKK PSSGKKGATT QNSEICSGQA PTPDQPDTSK RSK
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions: Concentrated protein in liquid format. Reconstitution is not necessary.
Concentration of Human Twinkle protein, mitochondrial Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
Recombinant Human Twinkle protein, mitochondrial Protein General Information | |
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Alternate Names | |
MTDPS7; PEO; PEOA3; TWINL; C10orf2; PRLTS5; SCA8; ATXN8; IOSCA; PEO1; SANDO | |
Curated Database and Bioinformatic Data | |
Gene Symbol | PEO1 |
Entrez Gene ID | 56652 |
Ensemble Gene ID | ENSG00000107815 |
RefSeq Protein Accession(s) | NP_001157284.1 |
RefSeq mRNA Accession(s) | NM_001163812.1, NM_021830.4 |
UniProt ID(s) | Q96RR1 |
UniGene ID(s) | Hs.22678 |
HGNC ID(s) | HGNC:1160 |
KEGG Gene ID(s) | hsa:56652 |
PharmGKB ID(s) | PA162377675 |
General Description of Recombinant Human Twinkle protein, mitochondrial Protein. | |
Involved in mitochondrial DNA (mtDNA) metabolism. Could function as an adenine nucleotide-dependent DNA helicase. Function inferred to be critical for lifetime maintenance of mtDNA integrity. In vitro, forms in combination with POLG, a processive replication machinery, which can use double-stranded DNA (dsDNA) as tplate to synthesize single-stranded DNA (ssDNA) molecules. May be a key regulator of mtDNA copy number in mammals. |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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