PDF DatasheetHuman F-box only protein 3 Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant F-box only protein 3 based upon sequence from Human
Host: QP9935 protein expressed in Yeast.
Tag: His
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) F-box only protein 3, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Recommended Applications: Immunogen, Protein Standard, Cell culture, or Other Cell Biology Applications.
Application Notes: Please contact us for application specific information for QP9935.
Bioactivity Data: Untested
Full Length? Full Length
Expression Region: Met1 – Phe471
Amino Acid Sequence: MAAMETETAP LTLESLPTDP LLLILSFLDY RDLINCCYVS RRLSQLSSHD PLWRRHCKKY WLISEEEKTQ KNQCWKSLFI DTYSDVGRYI DHYAAIKKAW DDLKKYLEPR CPRMVLSLKE GAREEDLDAV EAQIGCKLPD DYRCSYRIHN GQKLVVPGLL GSMALSNHYR SEDLLDVDTA AGGFQQRQGL KYCLPLTFCI HTGLSQYIAV EAAEGRNKNE VFYQCPDQMA RNPAAIDMFI IGATFTDWFT SYVKNVVSGG FPIIRDQIFR YVHDPECVAT TGDITVSVST SFLPELSSVH PPHYFFTYRI RIEMSKDALP EKACQLDSRY WRITNAKGDV EEVQGPGVVG EFPIISPGRV YEYTSCTTFS TTSGYMEGYY TFHFLYFKDK IFNVAIPRFH MACPTFRVSI ARLEMGPDEY EEMEEEEEEE EEEDEDDDSA DMDESDEDDE EERRRRVFDV PIRRRRCSRL F
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions: Concentrated protein in liquid format. Reconstitution is not necessary.
Concentration of Human F-box only protein 3 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human F-box only protein 3 Protein General Information | |
|---|---|
| Alternate Names | |
| FBA; FBX3 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | FBXO3 |
| Entrez Gene ID | 26273 |
| Ensemble Gene ID | ENSG00000110429 |
| RefSeq Protein Accession(s) | NP_036307.2 |
| RefSeq mRNA Accession(s) | NM_012175.3, NM_033406.2 |
| UniProt ID(s) | Q9UK99 |
| UniGene ID(s) | Hs.406787 |
| HGNC ID(s) | HGNC:13582 |
| COSMIC ID Link(s) | FBXO3 |
| KEGG Gene ID(s) | hsa:26273 |
| PharmGKB ID(s) | PA28040 |
| General Description of Recombinant Human F-box only protein 3 Protein. | |
| Substrate recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Mediates the ubiquitination of HIPK2 and probably that of EP300, leading to rapid degradation by the proteasome. In the presence of PML, HIPK2 ubiquitination still occurs, but degradation is prevented. PML, HIPK2 and FBXO3 may act synergically to activate p53/TP53-dependent transactivation. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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