PDF DatasheetHuman Ripk3 Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant Ripk3 based upon sequence from Human
Host: QP9945 protein expressed in Baculovirus, Yeast..
Tag: His-Myc
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) Ripk3, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Recommended Applications: Immunogen, Protein Standard, Cell culture, or Other Cell Biology Applications.
Application Notes: Please contact us for application specific information for QP9945.
Bioactivity Data: Untested
Full Length? Full Length
Expression Region: Met1 – Lys518
Amino Acid Sequence: MSCVKLWPSG APAPLVSIEE LENQELVGKG GFGTVFRAQH RKWGYDVAVK IVNSKAISRE VKAMASLDNE FVLRLEGVIE KVNWDQDPKP ALVTKFMENG SLSGLLQSQC PRPWPLLCRL LKEVVLGMFY LHDQNPVLLH RDLKPSNVLL DPELHVKLAD FGLSTFQGGS QSGTGSGEPG GTLGYLAPEL FVNVNRKAST ASDVYSFGIL MWAVLAGREV ELPTEPSLVY EAVCNRQNRP SLAELPQAGP ETPGLEGLKE LMQLCWSSEP KDRPSFQECL PKTDEVFQMV ENNMNAAVST VKDFLSQLRS SNRRFSIPES GQGGTEMDGF RRTIENQHSR NDVMVSEWLN KLNLEEPPSS VPKKCPSLTK RSRAQEEQVP QAWTAGTSSD SMAQPPQTPE TSTFRNQMPS PTSTGTPSPG PRGNQGAERQ GMNWSCRTPE PNPVTGRPLV NIYNCSGVQV GDNNYLTMQQ TTALPTWGLA PSGKGRGLQH PPPVGSQEGP KDPEAWSRPQ GWYNHSGK
Purity: Greater than 80% as determined by SDS-PAGE.
Reconstitution Instructions: Concentrated protein in liquid format. Reconstitution is not necessary.
Concentration of Human Ripk3 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human Ripk3 Protein General Information | |
|---|---|
| Alternate Names | |
| RIP3; Receptor-interacting serine/threonine-protein kinase | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | Ripk3 |
| Entrez Gene ID | 11035 |
| Ensemble Gene ID | ENSG00000129465 |
| RefSeq Protein Accession(s) | NP_006862.2 |
| RefSeq mRNA Accession(s) | NM_006871.3 |
| UniProt ID(s) | Q9Y572 |
| UniGene ID(s) | Hs.268551 |
| HGNC ID(s) | HGNC:10021 |
| COSMIC ID Link(s) | Ripk3 |
| KEGG Gene ID(s) | hsa:11035 |
| PharmGKB ID(s) | PA34396 |
| General Description of Recombinant Human Ripk3 Protein. | |
| Essential for necroptosis, a programmed cell death process in response to death-inducing TNF-alpha family members. Upon induction of necrosis, RIPK3 interacts with, and phosphorylates RIPK1 and MLKL to form a necrosis-inducing complex. RIPK3 binds to and enhances the activity of three metabolic enzymes: GLUL, GLUD1, and PYGL. These metabolic enzymes may eventually stimulate the tricarboxylic acid cycle and oxidative phosphorylation, which could result in enhanced ROS production. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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