PDF DatasheetHuman 5-hydroxytryptamine receptor 1B Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant 5-hydroxytryptamine receptor 1B based upon sequence from Human
Host: QP9954 protein expressed in Invitro-E.coli.
Tag: His
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) 5-hydroxytryptamine receptor 1B, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Recommended Applications: Immunogen, Protein Standard, Cell culture, or Other Cell Biology Applications.
Application Notes: Please contact us for application specific information for QP9954.
Bioactivity Data: Untested
Full Length? Full Length Transmembrane Protein
Expression Region: Met1 – Ser390
Amino Acid Sequence: MEEPGAQCAP PPPAGSETWV PQANLSSAPS QNCSAKDYIY QDSISLPWKV LLVMLLALIT LATTLSNAFV IATVYRTRKL HTPANYLIAS LAVTDLLVSI LVMPISTMYT VTGRWTLGQV VCDFWLSSDI TCCTASILHL CVIALDRYWA ITDAVEYSAK RTPKRAAVMI ALVWVFSISI SLPPFFWRQA KAEEEVSECV VNTDHILYTV YSTVGAFYFP TLLLIALYGR IYVEARSRIL KQTPNRTGKR LTRAQLITDS PGSTSSVTSI NSRVPDVPSE SGSPVYVNQV KVRVSDALLE KKKLMAARER KATKTLGIIL GAFIVCWLPF FIISLVMPIC KDACWFHLAI FDFFTWLGYL NSLINPIIYT MSNEDFKQAF HKLIRFKCTS
Purity: Greater than 85% as determined by SDS-PAGE.
Reconstitution Instructions: Concentrated protein in liquid format. Reconstitution is not necessary.
Concentration of Human 5-hydroxytryptamine receptor 1B Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human 5-hydroxytryptamine receptor 1B Protein General Information | |
|---|---|
| Alternate Names | |
| 5-HT1B; 5-HT-1B; 5-HT-1D-beta; HTR1D2; HTR1DB; 5-HT1DB; S12 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | HTR1B |
| Entrez Gene ID | 3351 |
| Ensemble Gene ID | ENSG00000135312 |
| RefSeq Protein Accession(s) | NP_000854.1 |
| RefSeq mRNA Accession(s) | NM_000863.2 |
| UniProt ID(s) | P28222 |
| UniGene ID(s) | Hs.123016 |
| HGNC ID(s) | HGNC:5287 |
| COSMIC ID Link(s) | HTR1B |
| KEGG Gene ID(s) | hsa:3351 |
| PharmGKB ID(s) | PA29549 |
| General Description of Recombinant Human 5-hydroxytryptamine receptor 1B Protein. | |
| G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for ergot alkaloid derivatives, various anxiolytic and antidepressant drugs and other psychoactive substances, such as lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Regulates the release of 5-hydroxytryptamine, dopamine and acetylcholine in the brain, and thereby affects neural activity, nociceptive processing, pain perception, mood and behavior. Besides, plays a role in vasoconstriction of cerebral arteries. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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