PDF DatasheetHuman KCNJ10 Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant KCNJ10 based upon sequence from Human
Host: QP9956 protein expressed in Invitro-E.coli.
Tag: His-SUMO
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) KCNJ10, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Recommended Applications: Immunogen, Protein Standard, Cell culture, or Other Cell Biology Applications.
Application Notes: Please contact us for application specific information for QP9956.
Bioactivity Data: Untested
Full Length? Full Length Transmembrane Protein
Expression Region: Met1 – Val379
Amino Acid Sequence: MTSVAKVYYS QTTQTESRPL MGPGIRRRRV LTKDGRSNVR MEHIADKRFL YLKDLWTTFI DMQWRYKLLL FSATFAGTWF LFGVVWYLVA VAHGDLLELD PPANHTPCVV QVHTLTGAFL FSLESQTTIG YGFRYISEEC PLAIVLLIAQ LVLTTILEIF ITGTFLAKIA RPKKRAETIR FSQHAVVASH NGKPCLMIRV ANMRKSLLIG CQVTGKLLQT HQTKEGENIR LNQVNVTFQV DTASDSPFLI LPLTFYHVVD ETSPLKDLPL RSGEGDFELV LILSGTVEST SATCQVRTSY LPEEILWGYE FTPAISLSAS GKYIADFSLF DQVVKVASPS GLRDSTVRYG DPEKLKLEES LREQAEKEGS ALSVRISNV
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions: Concentrated protein in liquid format. Reconstitution is not necessary.
Concentration of Human KCNJ10 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human KCNJ10 Protein General Information | |
|---|---|
| Alternate Names | |
| KIR4.1; KIR1.2; SESAME; KCNJ13-PEN; BIRK-10; ATP-sensitive inward rectifier potassium channel | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | KCNJ10 |
| Entrez Gene ID | 3766 |
| Ensemble Gene ID | ENSG00000177807 |
| RefSeq Protein Accession(s) | NP_002232.2 |
| RefSeq mRNA Accession(s) | NM_002241.4 |
| UniProt ID(s) | P78508 |
| UniGene ID(s) | Hs.408960 |
| HGNC ID(s) | HGNC:6256 |
| COSMIC ID Link(s) | KCNJ10 |
| KEGG Gene ID(s) | hsa:3766 |
| PharmGKB ID(s) | PA30043 |
| General Description of Recombinant Human KCNJ10 Protein. | |
| May be responsible for potassium buffering action of glial cells in the brain. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium and cesium (By similarity). In the kidney, together with KCNJ16, mediates basolateral K+ recycling in distal tubules; this process is critical for Na+ reabsorption at the tubules | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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