PDF DatasheetHuman CLIP-associating protein 2 Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant CLIP-associating protein 2 based upon sequence from Human
Isoform: Isoform 2
Host: QP9972 protein expressed in Invitro-E.coli.
Tag: His-B2M
Protein Construction: A DNA sequence encoding the Homo sapiens(Human) CLIP-associating protein 2, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Recommended Applications: Immunogen, Protein Standard, Cell culture, or Other Cell Biology Applications.
Application Notes: Please contact us for application specific information for QP9972.
Bioactivity Data: Untested
Full Length? Full Length of Isoform 2
Expression Region: Met1 – Val431
Amino Acid Sequence: MRRLICKRIC DYKSFDDEES VDGNRPSSAA SAFKVPAPKT SGNPANSARK PGSAGGPKVG GASKEGGAGA VDEDDFIKAF TDVPSIQIYS SRELEETLNK IREILSDDKH DWDQRANALK KIRSLLVAGA AQYDCFFQHL RLLDGALKLS AKDLRSQVVR EACITVAHLS TVLGNKFDHG AEAIVPTLFN LVPNSAKVMA TSGCAAIRFI IRHTHVPRLI PLITSNCTSK SVPVRRRSFE FLDLLLQEWQ THSLERHAAV LVETIKKGIH DADAEARVEA RKTYMGLRNH FPGEAETLYN SLEPSYQKSL QTYLKSSGSV ASLPQSDRSS SSSQESLNRP FSSKWSTANP STVAGRVSAG SSKASSLPGS LQRSRSDIDV NAAAGAKAHH AAGQSVRSGR LGAGALNAGS YASLECEAFW RSGRTAKLYS V
Purity: Greater than 85% as determined by SDS-PAGE.
Reconstitution Instructions: Concentrated protein in liquid format. Reconstitution is not necessary.
Concentration of Human CLIP-associating protein 2 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human CLIP-associating protein 2 Protein General Information | |
|---|---|
| Molecular Weight | |
| Isoform 2 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | CLASP2 |
| Entrez Gene ID | 23122 |
| Ensemble Gene ID | ENSG00000163539 |
| RefSeq Protein Accession(s) | NP_001193973.1 |
| RefSeq mRNA Accession(s) | NM_001207044.1, NM_015097.2 |
| UniProt ID(s) | O75122 |
| UniGene ID(s) | Hs.108614 |
| HGNC ID(s) | HGNC:17078 |
| COSMIC ID Link(s) | CLASP2 |
| KEGG Gene ID(s) | hsa:23122 |
| PharmGKB ID(s) | PA38435 |
| General Description of Recombinant Human CLIP-associating protein 2 Protein. | |
| Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules (PubMed:26003921). Involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN). Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2 (PubMed:16824950). This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3-kinase signaling. Also performs a similar stabilizing function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle (PubMed:16866869, PubMed:16914514). Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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