PDF DatasheetHuman Exportin-2 Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant Exportin-2 based upon sequence from Human
Host: QP9974 protein expressed in Invitro-E.coli.
Tag: His-SUMO
Protein Construction: A DNA sequence encoding the Homo sapiens(Human) Exportin-2, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Recommended Applications: Immunogen, Protein Standard, Cell culture, or Other Cell Biology Applications.
Application Notes: Please contact us for application specific information for QP9974.
Bioactivity Data: Untested
Full Length? Partial (see sequence information for more details).
Expression Region: Met1 – Asn200
Amino Acid Sequence: MELSDANLQT LTEYLKKTLD PDPAIRRPAE KFLESVEGNQ NYPLLLLTLL EKSQDNVIKV CASVTFKNYI KRNWRIVEDE PNKICEADRV AIKANIVHLM LSSPEQIQKQ LSDAISIIGR EDFPQKWPDL LTEMVNRFQS GDFHVINGVL RTAHSLFKRY RHEFKSNELW TEIKLVLDAF ALPLTNLFKA TIELCSTHAN
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions: Concentrated protein in liquid format. Reconstitution is not necessary.
Concentration of Human Exportin-2 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human Exportin-2 Protein General Information | |
|---|---|
| Alternate Names | |
| CAS; XPO2; CSE1 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | CSE1L |
| Entrez Gene ID | 1434 |
| Ensemble Gene ID | ENSG00000124207 |
| RefSeq Protein Accession(s) | NP_001243064.1 |
| RefSeq mRNA Accession(s) | NM_001256135.1, NM_001316.3, XM_011528599.2 |
| UniProt ID(s) | P55060 |
| UniGene ID(s) | Hs.90073 |
| HGNC ID(s) | HGNC:2431 |
| COSMIC ID Link(s) | CSE1L |
| KEGG Gene ID(s) | hsa:1434 |
| PharmGKB ID(s) | PA26933 |
| General Description of Recombinant Human Exportin-2 Protein. | |
| Export receptor for importin-alpha. Mediates importin-alpha re-export from the nucleus to the cytoplasm after import substrates (cargos) have been released into the nucleoplasm. In the nucleus binds cooperatively to importin-alpha and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the importin-alpha from the export receptor. CSE1L/XPO2 then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
There are no reviews yet.