PDF DatasheetMouse DPP4 / CD26 Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant DPP4 / CD26 based upon sequence from Mouse
Host: QP9975 protein expressed in Invitro-E.coli.
Tag: His-SUMO
Protein Construction: A DNA sequence encoding the Mus musculus (Mouse) DPP4 / CD26, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Recommended Applications: Immunogen, Protein Standard, Cell culture, or Other Cell Biology Applications.
Application Notes: Please contact us for application specific information for QP9975.
Bioactivity Data: Untested
Full Length? Extracellular Domain
Expression Region: Ser29 – His760
Amino Acid Sequence: SKDEAAADSR RTYSLADYLK STFRVKSYSL WWVSDFEYLY KQENNILLLN AEHGNSSIFL ENSTFESFGY HSVSPDRLFV LLEYNYVKQW RHSYTASYNI YDVNKRQLIT EEKIPNNTQW ITWSPEGHKL AYVWKNDIYV KVEPHLPSHR ITSTGEENVI YNGITDWVYE EEVFGAYSAL WWSPNNTFLA YAQFNDTGVP LIEYSFYSDE SLQYPKTVWI PYPKAGAVNP TVKFFIVNID SLSSSSSAAP IQIPAPASVA RGDHYLCDVV WATEERISLQ WLRRIQNYSV MAICDYDKIN LTWNCPSEQQ HVEMSTTGWV GRFRPAEPHF TSDGSSFYKI ISDKDGYKHI CHFPKDKKDC TFITKGAWEV ISIEALTSDY LYYISNQYKE MPGGRNLYKI QLTDHTNVKC LSCDLNPERC QYYAVSFSKE AKYYQLGCWG PGLPLYTLHR STDHKELRVL EDNSALDRML QDVQMPSKKL DFIVLNETRF WYQMILPPHF DKSKKYPLLL DVYAGPCSQK ADASFRLNWA TYLASTENII VASFDGRGSG YQGDKIMHAI NRRLGTLEVE DQIEAARQFV KMGFVDSKRV AIWGWSYGGY VTSMVLGSGS GVFKCGIAVA PVSRWEYYDS VYTERYMGLP IPEDNLDHYR NSTVMSRAEH FKQVEYLLIH GTADDNVHFQ QSAQISKALV DAGVDFQAMW YTDEDHGIAS STAHQHIYSH MSHFLQQCFS LH
Purity: Greater than 85% as determined by SDS-PAGE.
Reconstitution Instructions: Concentrated protein in liquid format. Reconstitution is not necessary.
Concentration of Mouse DPP4 / CD26 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Mouse DPP4 / CD26 Protein General Information | |
|---|---|
| Curated Database and Bioinformatic Data | |
| Gene Symbol | Dpp4 |
| Entrez Gene ID | 13482 |
| Ensemble Gene ID | ENSMUSG00000035000 |
| RefSeq Protein Accession(s) | NP_001153015.1 |
| RefSeq mRNA Accession(s) | NM_001159543.1, NM_010074.3 |
| UniProt ID(s) | P28843 |
| UniGene ID(s) | Mm.1151 |
| COSMIC ID Link(s) | Dpp4 |
| KEGG Gene ID(s) | mmu:13482 |
| General Description of Recombinant Mouse DPP4 / CD26 Protein. | |
| Cell surface glycoprotein receptor involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Acts as a positive regulator of T-cell coactivation, by binding at least ADA, CAV1, IGF2R, and PTPRC. Its binding to CAV1 and CARD11 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Its interaction with ADA also regulates lymphocyte-epithelial cell adhesion. In association with FAP is involved in the pericellular proteolysis of the extracellular matrix (ECM), the migration and invasion of endothelial cells into the ECM. May be involved in the promotion of lymphatic endothelial cells adhesion, migration and tube formation. When overexpressed, enhanced cell proliferation, a process inhibited by GPC3. Acts also as a serine exopeptidase with a dipeptidyl peptidase activity that regulates various physiological processes by cleaving peptides in the circulation, including many chemokines, mitogenic growth factors, neuropeptides and peptide hormones. Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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