PDF DatasheetHuman Sterol regulatory element-binding protein 1 Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant Sterol regulatory element-binding protein 1 based upon sequence from Human
Host: QP9983 protein expressed in Invitro-E.coli.
Tag: His
Protein Construction: A DNA sequence encoding the Homo sapiens(Human) Sterol regulatory element-binding protein 1, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Recommended Applications: Immunogen, Protein Standard, Cell culture, or Other Cell Biology Applications.
Application Notes: Please contact us for application specific information for QP9983.
Bioactivity Data: Untested
Full Length? Partial (see sequence information for more details).
Expression Region: Met1 – Leu490
Amino Acid Sequence: MDEPPFSEAA LEQALGEPCD LDAALLTDIE DMLQLINNQD SDFPGLFDPP YAGSGAGGTD PASPDTSSPG SLSPPPATLS SSLEAFLSGP QAAPSPLSPP QPAPTPLKMY PSMPAFSPGP GIKEESVPLS ILQTPTPQPL PGALLPQSFP APAPPQFSST PVLGYPSPPG GFSTGSPPGN TQQPLPGLPL ASPPGVPPVS LHTQVQSVVP QQLLTVTAAP TAAPVTTTVT SQIQQVPVLL QPHFIKADSL LLTAMKTDGA TVKAAGLSPL VSGTTVQTGP LPTLVSGGTI LATVPLVVDA EKLPINRLAA GSKAPASAQS RGEKRTAHNA IEKRYRSSIN DKIIELKDLV VGTEAKLNKS AVLRKAIDYI RFLQHSNQKL KQENLSLRTA VHKSKSLKDL VSACGSGGNT DVLMEGVKTE VEDTLTPPPS DAGSPFQSSP LSLGSRGSGS GGSGSDSEPD SPVFEDSKAK PEQRPSLHSR GMLDRSRLAL
Purity: Greater than 85% as determined by SDS-PAGE.
Reconstitution Instructions: Concentrated protein in liquid format. Reconstitution is not necessary.
Concentration of Human Sterol regulatory element-binding protein 1 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human Sterol regulatory element-binding protein 1 Protein General Information | |
|---|---|
| Alternate Names | |
| bHLHd1; SREBP-1c; SREBP1; SREBP1a | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | SREBF1 |
| Entrez Gene ID | 6720 |
| Ensemble Gene ID | ENSG00000072310 |
| RefSeq Protein Accession(s) | NP_001005291.1 |
| RefSeq mRNA Accession(s) | NM_001005291.2, NM_004176.4 |
| UniProt ID(s) | P36956 |
| UniGene ID(s) | Hs.592123 |
| HGNC ID(s) | HGNC:11289 |
| COSMIC ID Link(s) | SREBF1 |
| KEGG Gene ID(s) | hsa:6720 |
| PharmGKB ID(s) | PA335 |
| General Description of Recombinant Human Sterol regulatory element-binding protein 1 Protein. | |
| Transcriptional activator required for lipid homeostasis. Regulates transcription of the LDL receptor gene as well as the fatty acid and to a lesser degree the cholesterol synthesis pathway (By similarity). Binds to the sterol regulatory element 1 (SRE-1) (5′-ATCACCCCAC-3′). Has dual sequence specificity binding to both an E-box motif (5′-ATCACGTGA-3′) and to SRE-1 (5′-ATCACCCCAC-3′) | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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