PDF DatasheetHuman Anti-SOX4 (Master Regulator of Epithelial-Mesenchymal Transition) Antibody Product Attributes
Species: Human
Tested Applications: IHC.
Clonality: Monoclonal
Anti-SOX4 (Master Regulator of Epithelial-Mesenchymal Transition) Antibody Clone: SOX4/2540
Clone SOX4/2540 Host and Isotype: Mouse IgG2b, kappa
Anti-Human SOX4 (Master Regulator of Epithelial-Mesenchymal Transition) Positive Control Sample: Breast or Colon Carcinoma
Cellular Localization of Antibody SOX4/2540 Staining: Nuclear
Buffer and Stabilizer: 10mM PBS with 0.05% BSA & 0.05% azide. Also available without BSA & Azide.
Antibody Concentration: 200 ug/ml
Antibody Purification Method:Protein A/G purified from Bioreactor concentrate.
Immunogen: Recombinant full-length human SOX4 protein
Storage Conditions: Store at 2 to 8 C (refrigerate). Stable for 24 months when properly stored.
SOX4 (Master Regulator of Epithelial-Mesenchymal Transition) Previously Observed Antibody Staining Patterns
| SOX4 (Master Regulator of Epithelial-Mesenchymal Transition) General Information | |
|---|---|
| Alternate Names | |
| SOX; SRY (sex determining region Y) box 4; SRY box containing gene 4; SRY related HMG box gene 4; Transcription factor SOX-4 | |
| Molecular Weight | |
| 47kDa | |
| Chromosomal Location | |
| Ships on blue ice. | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | 6659 |
| Entrez Gene ID | SOX4 |
| UniProt ID(s) | Q06945 |
| UniGene ID(s) | Hs643910 |
| COSMIC ID Link(s) | SOX4 |
| KEGG Gene ID(s) | hsa:6659 |
| General Description of SOX4 (Master Regulator of Epithelial-Mesenchymal Transition). | |
| SOX4 is a member of the SOX (SRY-related HMG-box) family of transcription factors with a critical role in embryonic development and in cell-fate determination during organogenesis of the heart, pancreas, brain, and in B and T lymphocyte differentiation. SOX4 gene expression is upregulated in many cancer types, and increased SOX4 activity contributes to cellular transformation, cell survival, and metastasis. Gene expression profiling has uncovered SOX4 with upregulated activity during TGF-β-induced epithelial-mesenchymal transition (EMT) in normal and cancerous breast epithelial cells. SOX4 is indispensable for EMT and cell survival in vitro and for primary tumor growth and metastasis in vivo. SOX4 is identified as a master regulator of EMT by governing the expression of the epigenetic modifier Ezh2. | |
Limitations and Warranty
enQuire Bio’s product, SOX4 (Master Regulator of Epithelial-Mesenchymal Transition) MonoSpecific Antibody, is available for Research Use Only (RUO-Only). This antibody is guaranteed to work for a period of two years when properly stored.
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