Human Anti-SOX2 Antibody Product Attributes
Species: Human
Tested Applications: Immunohistochemistry (IHC).
Clonality: Monoclonal
Anti-SOX2 Antibody Clone: SOX2/1792
Clone SOX2/1792 Host and Isotype: Mouse IgG2b kappa
Anti-Human SOX2 Positive Control Sample: MCF-7 cells or Cervical carcinoma
Cellular Localization of Antibody Nuclear
Buffer and Stabilizer: 10mM PBS with 0.05% BSA and 0.05% Azide
Antibody Concentration: 200 ug/ml
Antibody Purification Method:Protein A/G Purified
Immunogen: Recombinant human SOX2 protein fragment (aa176-305)
Storage Conditions: Store at 2 to 8° C (refrigerate). Stable for 24 months when properly stored.
SOX2 Previously Observed Antibody Staining Patterns
Observed Subcellular, Organelle Specific Staining Data:
Anti-SOX2 antibody staining is expected to be primarily localized to the nucleoplasm.Observed Antibody Staining Data By Tissue Type:
Variations in SOX2 antibody staining intensity in immunohistochemistry on tissue sections are present across different anatomical locations. Low, but measureable presence of SOX2 could be seen inrespiratory epithelial cells in the bronchus, glial cells in the cerebral cortex, neuronal cells in the cerebral cortex, squamous epithelial cells in the cervix, uterine and esophagus, respiratory epithelial cells in the nasopharynx, squamous epithelial cells in the oral mucosa, fibroblasts in mesenchymal tissue, germinal center cells in the tonsil and squamous epithelial cells in the vagina. We were unable to detect SOX2 in other tissues. Disease states, inflammation, and other physiological changes can have a substantial impact on antibody staining patterns. These measurements were all taken in tissues deemed normal or from patients without known disease.Observed Antibody Staining Data By Tissue Disease Status:
Tissues from cancer patients, for instance, have their own distinct pattern of SOX2 expression as measured by anti-SOX2 antibody immunohistochemical staining. The average level of expression by tumor is summarized in the table below. The variability row represents patient to patient variability in IHC staining.| Sample Type | breast cancer | carcinoid | cervical cancer | colorectal cancer | endometrial cancer | glioma | head and neck cancer | liver cancer | lung cancer | lymphoma | melanoma | ovarian cancer | pancreatic cancer | prostate cancer | renal cancer | skin cancer | stomach cancer | testicular cancer | thyroid cancer | urothelial cancer |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Signal Intensity | - | + | + | + | - | + | + | - | - | - | - | - | - | - | - | - | - | - | - | - |
| SOX2 Variability | ++ | ++ | ++ | ++ | + | ++ | ++ | ++ | ++ | + | + | + | + | + | + | + | + | ++ | ++ | ++ |
Limitations and Warranty
enQuire Bio's SOX2 Anti-Human Monoclonal is available for Research Use Only. This antibody is guaranteed to work for a period of two years when properly stored.
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