Human peripheral blood granulocytes were stained with 5 uL  (solid line) or 0.25 ug APC Mouse IgG1 isotype control (dashed line). Flow Cytometry Data from 10,000 events.

Human Anti-CD10 Antibody [SN5c]

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SKU: QAB21
Species: Human
Tested Applications: Flow Cytometry
Available Conjugates: APC ;PE-Cy7
Isotype: Mouse IgG1 kappa
Mass Spec Validated?: Not MS Validated

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Datasheets and Documentation
Product Datasheet
SKU: QAB21-APC-25Tests
CD10 / Neprilysin / MME General Information
Alternate Names
CD1, Neprilysin, MME, C85356, SFE, NEP, CD1, 63454K5Rik, CALLA
Curated Database and Bioinformatic Data
Gene SymbolMME
Entrez Gene ID4311
Ensemble Gene IDENSG00000196549
RefSeq Protein Accession(s)XP_006713710, NP_001341571, XP_011511157, NP_009218, NP_009220, XP_011511159, NP_000893, NP_001341573, XP_006713709, XP_011511158, NP_001341572, NP_009219
RefSeq mRNA Accession(s)XM_006713647, NM_001354642, NM_001354643, NM_007289, XM_011512856 NM_007287, XM_006713646, NM_007288, XM_011512855, XM_011512857, NM_000902, NM_001354644
RefSeq Genomic Accession(s)NG_051105, NC_000003, NC_018914
UniProt ID(s)P08473
UniGene ID(s)P08473
HGNC ID(s)7154
Cosmic ID(s)MME
KEGG Gene ID(s)hsa:4311
PharmGKB ID(s)PA30864
General Description of CD10 / Neprilysin / MME.
The SN5c antibody is specific for human CD10, a 100 kDa type II transmembrane protein also known as Common Acute Lymphoblastic Leukemia Antigen (CALLA). In normal cells, it is expressed on early B and T lymphoid precursors, neutrophils and on various epithelia. CD10 is also expressed on several lymphoma cells including Burkitts, acute lymphoblastic, and follicular germinal center lymphomas. CD10 functions as an endopeptidase and is involved in B cell development, as well as a mediator of neutrophil inflammatory responses.

Human Anti-CD10 / Neprilysin / MME Antibody Product Attributes

Species: Human
Tested Applications: Flow Cytometry.
Application Notes: 5 ul per test where one test represents staining of a cell sample in a final volume of approximately 100 uL. The number of cells within a sample must be experimentally determined, but ranges between 1x105 to 1x108 cells.
Clonality: Monoclonal Antibody
Anti-CD10 / Neprilysin / MME Antibody Clone: SN5c
Clone SN5c Host and Isotype: Mouse IgG1 kappa
Buffer and Stabilizer: 10 mM NaH2PO4, 150 mM NaCl, 0.09% NaN3, 0.1% gelatin, pH7.2
Antibody Concentration: 5 uL /test
Storage Conditions: 2-8C protected from light. Stable for 12 Months. Do Not Freeze.

CD10 / Neprilysin / MME Previously Observed Antibody Staining Patterns

Observed Antibody Staining Data By Tissue Type:

Variations in CD10 / Neprilysin / MME antibody staining intensity in immunohistochemistry on tissue sections are present across different anatomical locations. An intense signal was observed in cells in the glomeruli in kidney, cells in the tubules in kidney and glandular cells in the duodenum, prostate and small intestine. More moderate antibody staining intensity was present in cells in the glomeruli in kidney, cells in the tubules in kidney and glandular cells in the duodenum, prostate and small intestine. Low, but measureable presence of CD10 / Neprilysin / MME could be seen inmacrophages in lung. We were unable to detect CD10 / Neprilysin / MME in other tissues. Disease states, inflammation, and other physiological changes can have a substantial impact on antibody staining patterns. These measurements were all taken in tissues deemed normal or from patients without known disease.

Selected References

Matsuzaki H, Haruta Y, Fukukawa T, Barcos MP and Seon BK. 1987. Cancer Res. 47(8): 2160-2166. Shipp MA, Stefano GB, Switzer SN, Griffin JD and Reinherz EL. 1991. Blood. 78(7): 1834-1841. Pinho S, Lacombe J, Hanoun M, Mizoguchi T, Bruns I, Kunisaki Y and Frenette PS. 2013. J Exp Med. 201(7): 1351-1367. (Flow cytometry) Mukhopadhyay C, Zhao X, Maroni D, Band V and Naramura M. 2013. PLoS One. 8(10): e75907. (Flow cytometry)

Limitations and Warranty

enQuire Bio's Human Anti-CD10 Monoclonal is available for Research Use Only. This antibody is guaranteed to work for a period of two years when properly stored.

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