Human Anti-CD38 Antibody [HB7]

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SKU: QAB92
Species: Human
Tested Applications: Flow Cytometry
Available Conjugates: PE
Isotype: Mouse IgG1 kappa
Mass Spec Validated?: Not MS Validated

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Datasheets and Documentation
Product Datasheet
SKU: QAB92-PE-25Tests
CD38 General Information
Alternate Names
CD38, ADPRC1, ADPRC 1
Curated Database and Bioinformatic Data
Gene SymbolCD38
Entrez Gene ID952
Ensemble Gene IDENSG00000004468
RefSeq Protein Accession(s)NP_001766
RefSeq mRNA Accession(s)NM_001775, NR_132660
RefSeq Genomic Accession(s)NC_000004, NC_018915
UniProt ID(s)P28907, B4E006
UniGene ID(s)P28907, B4E006
HGNC ID(s)1667
Cosmic ID(s)CD38
KEGG Gene ID(s)hsa:952
PharmGKB ID(s)PA26214
General Description of CD38.
The HB7 antibody is specific for human CD38, a 45 kDa type II transmembrane glycoprotein expressed on thymocytes, plasma cells, and monocytes as well as other non-hematopoietic cells. T and B lymphocyte expression is discontinuous and varies based on differentiation state present on immature cells, low on intermediate stages, and high on activated mature cells. It is found on most CD34+ cells, but not on pluripotent stem cells. CD38 is an ectoenzyme that functions to catalyze the synthesis and hydrolysis of cyclic ADP-ribose and is involved in cell signaling, regulating cell adhesion, and activation. Additionally, CD38 has been shown to be a prognostic marker for some leukemias and other diseases.

Human Anti-CD38 Antibody Product Attributes

Species: Human
Tested Applications: Flow Cytometry.
Application Notes: 5 ul per test where one test represents staining of a cell sample in a final volume of approximately 100 uL. The number of cells within a sample must be experimentally determined, but ranges between 1x105 to 1x108 cells.
Clonality: Monoclonal Antibody
Anti-CD38 Antibody Clone: HB7
Clone HB7 Host and Isotype: Mouse IgG1 kappa
Buffer and Stabilizer: 10 mM NaH2PO4, 150 mM NaCl, 0.09% NaN3, 0.1% gelatin, pH7.2
Antibody Concentration: 5 uL /test
Storage Conditions: 2-8C protected from light. Stable for 12 Months. Do Not Freeze.

CD38 Previously Observed Antibody Staining Patterns

Observed Subcellular, Organelle Specific Staining Data:

Staining with anti-CD38 antibody reveals CD38 expression is expected to be primarily localized to the plasma membrane.

Observed Antibody Staining Data By Tissue Type:

Variations in CD38 antibody staining intensity in immunohistochemistry on tissue sections are present across different anatomical locations. An intense signal was observed in glandular cells in the prostate and seminal vesicle and non-germinal center cells in the lymph node and tonsil. More moderate antibody staining intensity was present in glandular cells in the prostate and seminal vesicle and non-germinal center cells in the lymph node and tonsil. Low, but measureable presence of CD38 could be seen in. We were unable to detect CD38 in other tissues. Disease states, inflammation, and other physiological changes can have a substantial impact on antibody staining patterns. These measurements were all taken in tissues deemed normal or from patients without known disease.

Observed Antibody Staining Data By Tissue Disease Status:

Tissues from cancer patients, for instance, have their own distinct pattern of CD38 expression as measured by anti-CD38 antibody immunohistochemical staining. The average level of expression by tumor is summarized in the table below. The variability row represents patient to patient variability in IHC staining.

Sample Type breast cancer carcinoid cervical cancer colorectal cancer endometrial cancer glioma head and neck cancer liver cancer lung cancer lymphoma melanoma ovarian cancer pancreatic cancer prostate cancer renal cancer skin cancer stomach cancer testicular cancer thyroid cancer urothelial cancer
Signal Intensity - - - - - - - - - - - - - - - - - - - -
CD38 Variability + + + + + + + + + + + + + + + + + + ++ +

Selected References

Tedder TF, Clement LT and Cooper MD. 1984. Tissue Antigens. 24(3): 140-149. (Flow cytometry) Jackson DG and Bell JI. 1990. J Immunol. 144(7): 2811-2815. Mahta K, Shahid U and Malavasi F. 1996. FASEB J. 10(12): 1408-1417. Ferrero E and Malavasi F. 1999. J Leukoc Biol. 65(2): 151-161. Llinas L, Lazaro A, de Saolrt J, Matesanz-Isabel J, Sintes J and Engel P. 2011. Immunol Lett. 134(2): 113-121. (Flow cytometry)

Limitations and Warranty

enQuire Bio's Human Anti-CD38 Monoclonal is available for Research Use Only. This antibody is guaranteed to work for a period of two years when properly stored.

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