Immunohistochemical staining of Cytokeratin 13  of human FFPE tissue followed by incubation with HRP labeled secondary and development with DAB substrate.

Cytokeratin 13 [KS-1A3] Antibody (cGMP).

$ 135.00$ 325.00
Please Select Product Options Below To View The Catalog Number.

SKU: QIVD114
Species: Human
Tested Applications: IHC [IVD]
Available Conjugates:
Isotype: Mouse IgG1

Product NumberDescriptionPrice
QIVD114-0.1ml Size: 0.1 ml, Format: Concentrate $ 135.00
QIVD114-0.5ml Size: 0.5 ml, Format: Concentrate $ 195.00
QIVD114-1ml Size: 1 ml, Format: Concentrate $ 325.00
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Datasheets and Documentation
Product Datasheet
Certificate of Analysis and Tags (Coming Soon)
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SKU: QIVD114-0.1ml
Cytokeratin 13 General Information
Alternate Names
Molecular Weight
49.6 kDa
Chromosomal Location
q21.2 [chr: 17] [chr_start: 41500981] [chr_end: 41505705] [strand: -1]
Curated Database and Bioinformatic Data
Gene SymbolKRT13
Entrez Gene ID3860
RefSeq Protein Accession(s)NP_705694; NP_002265
RefSeq mRNA Accession(s)NM_002274; NM_153490;
RefSeq Genomic Accession(s)NG_008406; NC_000017
UniProt ID(s)P13646
PharmGKB ID(s)PA30202
KEGG Gene ID(s)hsa:3860
Associated Diseases (KEGG IDs)White sponge nevus 2 (WSN2) [MIM:615785]: A rare disorder characterized by the presence of soft, white, and spongy plaques in the oral mucosa. The characteristic histopathologic features are epithelial thickening, parakeratosis, and vacuolization of the suprabasal layer of oral epithelial keratinocytes. Less frequently the mucous membranes of the nose, esophagus, genitalia and rectum are involved. {ECO:0000269|PubMed:10561721, ECO:0000269|PubMed:11379896, ECO:0000269|PubMed:14600690, ECO:0000269|PubMed:7493031}. The disease is caused by mutations affecting the gene represented in this entry.
General Description of Cytokeratin 13 .
This antibody is specific to 54 kDa protein. Cytokeratin 13 belongs to the type A (acidic) subfamily of low molecular weight cytokeratins and exists in combination with cytokeratin 4. Cytokeratin 13 is expressed in squamous, non-keratinized epithelium, transitional epithelium and myoepithelium. This antibody is useful for the identification of carcinomas of trachea, sweat glands, bladder, ectocervix, tongue, esophagus, anal canal and the basal layer of keratinized epidermis.

Antibody (Suitable for clinical applications)

Sample Type: FFPE Patient Samples.
Tested Applications: IHC. Approved for In Vitro Diagnostic Procedures on FFPE tissues. For tissue collection recommendations, please see datasheet sent with product.
Application Notes
Specification Recommendation
Recommended Dilution (Conc) 1:25-1:100
Pretreatment Citrate Buffer pH 6.0
Incubation Parameters 30 min at Room Temperature

Prior to use, inspect vial for the presence of any precipitate or other unusual physical properties. These can indicate that the antibody has degraded and is no longer suitable for patient samples. Please run positive and negative controls simultaneously with all patient samples to account and control for errors in laboratory procedure. Use of methods or materials not recommended by enQuire Bio including change to dilution range and detection system should be routinely validated by the user.

Clonality: Monoclonal
Anti-Cytokeratin 13 Antibody Clone: KS-1A3
Host and Isotype: Mouse IgG1
Recommended Positive Control Sample: Skin
Cellular Localization of Antibody KS-1A3 Staining: Cytoplasmic
Buffer and Stabilizer: PBS with 1% BSA and 0.05% NaN3
Antibody Concentration: Lot specific. Plese contact tech support for data.
Immunogen: Cultured A431 cells from a human epidermoid carcinoma of the vulva.
Storage Conditions: This antibody should be stored refrigerated (2-8°C). This product should not be used past the expiration date printed on the vial.

Cytokeratin 13 Information for Pathologists

Summary:

Molecular weight is 53 kDa. Pairs with CK4. Marker of mature but non-keratinized squamous epithelium. Downregulated in squamous cell carcinoma of head and neck (Oral Oncol 2005;41:183) and other sites (Virchows Arch A Pathol Anat Histopathol 1991;418:249). Sensitive marker for retinoid bioactivity in skin warts of renal transplant recipients (Arch Dermatol 2002;138:61).

Common Uses By Pathologists:

No significant clinical use by pathologists. Positive staining - normal Suprabasal layers of non-cornified stratified epithelium, including squamous (non-keratinized) epithelia of cervix, esophagus, larynx, oral cavity, tonsils, urothelium, and respiratory-type epithelium. May be filled with mucoid material or foamy macrophages. Positive staining - disease

Limitations and Warranty

This antibody is manufactured in accordance with clinical good manufacturing practices in an ISO13485:2016 certified production facility. It is intended for multiple uses including in vitro diagnostic use and research use only applications. Please see vial label for expiration date. We strive to always deliver antibodies with a shelf life of at least two years.

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Cytokeratin 13 [KS-1A3] Antibody (cGMP).