Formalin-fixed, paraffin-embedded human Skin stained with Cytokeratin, HMW Recombinant Rabbit Monoclonal Antibody (KRTH/1576R).
Formalin-fixed, paraffin-embedded human Skin stained with Cytokeratin, HMW Recombinant Rabbit Monoclonal Antibody (KRTH/1576R).

Anti-Cytokeratin, Basic Antibody Clone KRTH/1576R

$ 178.00$ 498.00
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SKU: RBM22-1576
Species: Human
Tested Applications: Immunohistochemistry (IHC)
Available Conjugates: Unconjugated
Isotype: Rabbit IgG kappa
Mass Spec Validated?: Not MS Validated

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Datasheets and Documentation
Product Datasheet
SKU: RBM22-1576-P0
Cytokeratin, Basic General Information
Alternate Names
KRT2B, KRT2P, HUMCYT2A, Keratin, type II Cytoskeletal 2 oral, K76, Keratin 2p (K2P), Keratin-76, Cytokeratin-2P (CK-2P, Type-II Keratin Kb9, anti-KRT2B antibody, anti-KRT2P antibody, anti-HUMCYT2A antibody, anti-Keratin, type II Cytoskeletal 2 oral antibody, anti-K76 antibody, anti-Keratin 2p (K2P) antibody, anti-Keratin-76 antibody, anti-Cytokeratin-2P (CK-2P antibody, anti-Type-II Keratin Kb9 antibody
Molecular Weight
52-67kDa
Chromosomal Location
12q13.13
Curated Database and Bioinformatic Data
Gene SymbolKRT76
Entrez Gene ID51350
Ensemble Gene IDENSG00000185069
RefSeq Protein Accession(s)NP_056932
RefSeq mRNA Accession(s)NM_015848,
RefSeq Genomic Accession(s)NG_012420, NC_000012, NC_018923
UniProt ID(s)Q01546
UniGene ID(s)Q01546
HGNC ID(s)24430
Cosmic ID(s)KRT76
KEGG Gene ID(s)hsa:51350
PharmGKB ID(s)PA147357785
General Description of Cytokeratin, Basic.
This MAb recognizes basic (Type II or HMW) cytokeratins, which include 67kDa (CK1); 64kDa (CK3); 59kDa (CK4); 58kDa (CK5); 56kDa (CK6); 52kDa (CK8). Twenty human keratins are resolved with two-dimensional gel electrophoresis into acidic (pI 6.0) subfamilies. The acidic keratins have molecular weights (MW) of 56.5, 55, 51, 50, 50 , 48, 46, 45, and 40kDa. MAb AE3 recognizes the 65-67, 64, 59, 58, 56, and 52kDa keratins of basic subfamily. Many studies have shown the usefulness of keratins as markers in cancer research and tumor diagnosis.

Human Anti-Cytokeratin, Basic Antibody Product Attributes

Species: Human
Tested Applications: Immunohistochemistry (IHC).
Clonality: Recombinant Monoclonal
Anti-Cytokeratin, Basic Antibody Clone: KRTH/1576R
Clone KRTH/1576R Host and Isotype: Rabbit IgG kappa
Anti-Human Cytokeratin, Basic Positive Control Sample: Epithelial cells, Skin or Adenocarcinomas
Cellular Localization of Antibody Cytoplasmic
Buffer and Stabilizer: 10mM PBS with or without 0.05% BSA & 0.05% azide.
Antibody Concentration: 200ug/ml
Antibody Purification Method:Protein A/G Purified
Immunogen: Recombinant full-length human KRT76 protein
Storage Conditions: Store at 2 to 8° C (refrigerate). Stable for 24 months when properly stored.

Cytokeratin, Basic Previously Observed Antibody Staining Patterns

Observed Antibody Staining Data By Tissue Type:

Variations in Cytokeratin, Basic antibody staining intensity in immunohistochemistry on tissue sections are present across different anatomical locations. Low, but measureable presence of Cytokeratin, Basic could be seen in. We were unable to detect Cytokeratin, Basic in other tissues. Disease states, inflammation, and other physiological changes can have a substantial impact on antibody staining patterns. These measurements were all taken in tissues deemed normal or from patients without known disease.

Observed Antibody Staining Data By Tissue Disease Status:

Tissues from cancer patients, for instance, have their own distinct pattern of Cytokeratin, Basic expression as measured by anti-Cytokeratin, Basic antibody immunohistochemical staining. The average level of expression by tumor is summarized in the table below. The variability row represents patient to patient variability in IHC staining.

Sample Type breast cancer carcinoid cervical cancer colorectal cancer endometrial cancer glioma head and neck cancer liver cancer lung cancer lymphoma melanoma ovarian cancer pancreatic cancer prostate cancer renal cancer skin cancer stomach cancer testicular cancer thyroid cancer urothelial cancer
Signal Intensity + - - + + - + + - - - + + - - - - - + -
KRT76 Variability ++ ++ ++ ++ ++ + ++ ++ ++ + ++ ++ ++ ++ ++ + ++ ++ ++ ++

Limitations and Warranty

enQuire Bio's Cytokeratin, Basic Recombinant Monoclonal is available for Research Use Only. This antibody is guaranteed to work for a period of two years when properly stored.

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