.jpg "Desmocollin-2 3 IHC human Skin (7G6)")
Human, Mouse, and Rat Anti-Desmocollin-2/3 Antibody Product Attributes
Species: Human, Mouse, and Rat
Tested Applications: Immunohistochemistry (IHC).
Clonality: Monoclonal
Anti-Desmocollin-2/3 Antibody Clone: 7G6
Clone 7G6 Host and Isotype: Mouse IgG1 kappa
Anti-Human, Mouse, and Rat Desmocollin-2/3 Positive Control Sample: HeLa cells. Skin
Cellular Localization of Antibody <7G6 Staining: Cell surface
Buffer and Stabilizer: 10mM PBS with 0.05% BSA and 0.05% Azide
Antibody Concentration: 200 ug/ml
Antibody Purification Method:Protein A/G Purified
Immunogen: Human desmocollin-2 extracellular domain
Storage Conditions: Store at 2 to 8° C (refrigerate). Stable for 24 months when properly stored.
Desmocollin-2/3 Previously Observed Antibody Staining Patterns
Observed Antibody Staining Data By Tissue Type:
Variations in Desmocollin-2/3 antibody staining intensity in immunohistochemistry on tissue sections are present across different anatomical locations. An intense signal was observed in epidermal cells in the skin, glandular cells in the appendix, endometrium, rectum and small intestine, myocytes in heart muscle and squamous epithelial cells in the esophagus, oral mucosa, tonsil and vagina. More moderate antibody staining intensity was present in epidermal cells in the skin, glandular cells in the appendix, endometrium, rectum and small intestine, myocytes in heart muscle and squamous epithelial cells in the esophagus, oral mucosa, tonsil and vagina. Low, but measureable presence of Desmocollin-2/3 could be seen inglandular cells in the endometrium, epididymis, gallbladder, seminal vesicle and thyroid gland, hepatocytes in liver, keratinocytes in skin, macrophages in lung, respiratory epithelial cells in the bronchus, urothelial cells in the urinary bladder and glandular cells in the endometrium, epididymis, gallbladder and seminal vesicle and thyroid gland. We were unable to detect Desmocollin-2/3 in other tissues. Disease states, inflammation, and other physiological changes can have a substantial impact on antibody staining patterns. These measurements were all taken in tissues deemed normal or from patients without known disease.Observed Antibody Staining Data By Tissue Disease Status:
Tissues from cancer patients, for instance, have their own distinct pattern of Desmocollin-2/3 expression as measured by anti-Desmocollin-2/3 antibody immunohistochemical staining. The average level of expression by tumor is summarized in the table below. The variability row represents patient to patient variability in IHC staining.| Sample Type | breast cancer | carcinoid | cervical cancer | colorectal cancer | endometrial cancer | glioma | head and neck cancer | liver cancer | lung cancer | lymphoma | melanoma | ovarian cancer | pancreatic cancer | prostate cancer | renal cancer | skin cancer | stomach cancer | testicular cancer | thyroid cancer | urothelial cancer |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Signal Intensity | - | - | ++ | ++ | ++ | - | + | + | ++ | - | - | ++ | ++ | ++ | - | ++ | ++ | + | + | ++ |
| DSC2 Variability | ++ | ++ | ++ | ++ | ++ | + | +++ | ++ | + | + | + | ++ | ++ | + | ++ | ++ | ++ | ++ | ++ | ++ |
Limitations and Warranty
enQuire Bio's Desmocollin-2/3 Anti-Human Monoclonal is available for Research Use Only. This antibody is guaranteed to work for a period of two years when properly stored.
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