Formalin-fixed, paraffin-embedded human Skin stained with Desmocollin-2/3 Monoclonal Antibody (7G6).
Formalin-fixed, paraffin-embedded human Skin stained with Desmocollin-2/3 Monoclonal Antibody (7G6).

Anti-Desmocollin-2/3 Antibody Clone 7G6

$ 118.00$ 418.00
Please Select Product Options Below To View The Catalog Number.

SKU: 1824-MSM1
Species: Human, Mouse, and Rat
Tested Applications: Immunohistochemistry (IHC)
Available Conjugates: Unconjugated
Isotype: Mouse IgG1 kappa
Mass Spec Validated?: Not MS Validated

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Datasheets and Documentation
Product Datasheet
SKU: 1824-MSM1-P0
Desmocollin-2/3 General Information
Alternate Names
Desmocollin-2, DSC2
Molecular Weight
110kDa (DSC2) ;100kDa (DSC3)
Chromosomal Location
18q12.1
Curated Database and Bioinformatic Data
Gene SymbolDSC2
Entrez Gene ID1824
Ensemble Gene IDENSG00000134755
RefSeq Protein Accession(s)XP_005258263, NP_004940, NP_077740
RefSeq mRNA Accession(s)XM_005258206, NM_004949, NM_024422
RefSeq Genomic Accession(s)NC_018929, NG_008208, NC_000018
UniProt ID(s)Q02487
UniGene ID(s)Q02487
HGNC ID(s)3036
Cosmic ID(s)DSC2
KEGG Gene ID(s)hsa:1824
PharmGKB ID(s)PA27489
General Description of Desmocollin-2/3.
Desmosomes are intercellular adhering junctions that represent cell surface attachment sites for intermediate filament. The desmosome is subdivided into two regions. The plaque region lies adjacent to the plasma, and is believed to contain molecules that attach the intermediate filament cytoskeleton to the desmosome. The core region is composed of transmembrane glycoproteins that are thought to mediate cell-cell adhesion. Desmogleins and desmocollins are the main desmosomal transmembrane proteins. These desmosomal glycoproteins belong to the members of the cadherin family of adhesion molecules. Three different isoforms of both desmogleins and desmocollins have been identified, named as desmoglein 1-3 and desmocollins. Desmosomal cadherins showed differentiation-specific expression in the human epidermis, although the functional significance of this differential expression is not fully understood. Desmocollin-1 can be found in the upper layers. The expression of desmocollin-2 varies in the basal and suprabasal layers. And desmocollin-3 is expressed more evenly throughout the suprabasal layers.

Human, Mouse, and Rat Anti-Desmocollin-2/3 Antibody Product Attributes

Species: Human, Mouse, and Rat
Tested Applications: Immunohistochemistry (IHC).
Clonality: Monoclonal
Anti-Desmocollin-2/3 Antibody Clone: 7G6
Clone 7G6 Host and Isotype: Mouse IgG1 kappa
Anti-Human, Mouse, and Rat Desmocollin-2/3 Positive Control Sample: HeLa cells. Skin
Cellular Localization of Antibody Cell surface
Buffer and Stabilizer: 10mM PBS with 0.05% BSA and 0.05% Azide
Antibody Concentration: 200 ug/ml
Antibody Purification Method:Protein A/G Purified
Immunogen: Human desmocollin-2 extracellular domain
Storage Conditions: Store at 2 to 8° C (refrigerate). Stable for 24 months when properly stored.

Desmocollin-2/3 Previously Observed Antibody Staining Patterns

Observed Antibody Staining Data By Tissue Type:

Variations in Desmocollin-2/3 antibody staining intensity in immunohistochemistry on tissue sections are present across different anatomical locations. An intense signal was observed in epidermal cells in the skin, glandular cells in the appendix, endometrium, rectum and small intestine, myocytes in heart muscle and squamous epithelial cells in the esophagus, oral mucosa, tonsil and vagina. More moderate antibody staining intensity was present in epidermal cells in the skin, glandular cells in the appendix, endometrium, rectum and small intestine, myocytes in heart muscle and squamous epithelial cells in the esophagus, oral mucosa, tonsil and vagina. Low, but measureable presence of Desmocollin-2/3 could be seen inglandular cells in the endometrium, epididymis, gallbladder, seminal vesicle and thyroid gland, hepatocytes in liver, keratinocytes in skin, macrophages in lung, respiratory epithelial cells in the bronchus, urothelial cells in the urinary bladder and glandular cells in the endometrium, epididymis, gallbladder and seminal vesicle and thyroid gland. We were unable to detect Desmocollin-2/3 in other tissues. Disease states, inflammation, and other physiological changes can have a substantial impact on antibody staining patterns. These measurements were all taken in tissues deemed normal or from patients without known disease.

Observed Antibody Staining Data By Tissue Disease Status:

Tissues from cancer patients, for instance, have their own distinct pattern of Desmocollin-2/3 expression as measured by anti-Desmocollin-2/3 antibody immunohistochemical staining. The average level of expression by tumor is summarized in the table below. The variability row represents patient to patient variability in IHC staining.

Sample Type breast cancer carcinoid cervical cancer colorectal cancer endometrial cancer glioma head and neck cancer liver cancer lung cancer lymphoma melanoma ovarian cancer pancreatic cancer prostate cancer renal cancer skin cancer stomach cancer testicular cancer thyroid cancer urothelial cancer
Signal Intensity - - ++ ++ ++ - + + ++ - - ++ ++ ++ - ++ ++ + + ++
DSC2 Variability ++ ++ ++ ++ ++ + +++ ++ + + + ++ ++ + ++ ++ ++ ++ ++ ++

Limitations and Warranty

enQuire Bio's Desmocollin-2/3 Anti-Human Monoclonal is available for Research Use Only. This antibody is guaranteed to work for a period of two years when properly stored.

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