Formalin-fixed, paraffin-embedded human Skin stained with Desmoglein-1 Monoclonal Antibody (DSG1/1733).
Formalin-fixed, paraffin-embedded human Skin stained with Desmoglein-1 Monoclonal Antibody (DSG1/1733).

Anti-Desmoglein-1 Antibody Clone DSG1/1733

$ 118.00$ 418.00
Please Select Product Options Below To View The Catalog Number.

SKU: 1828-MSM3
Species: Human
Tested Applications: Immunohistochemistry (IHC)
Available Conjugates: Unconjugated
Isotype: Mouse IgG1 kappa
Mass Spec Validated?: Not MS Validated

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Datasheets and Documentation
Product Datasheet
SKU: 1828-MSM3-P0
Desmoglein-1 General Information
Alternate Names
Desmoglein-1, DSG1
Molecular Weight
150kDa (precursor) ;160kDa (mature)
Chromosomal Location
18q12.1
Curated Database and Bioinformatic Data
Gene SymbolDSG1
Entrez Gene ID1828
Ensemble Gene IDENSG00000134760
RefSeq Protein Accession(s)NP_001933
RefSeq mRNA Accession(s)NM_001942
RefSeq Genomic Accession(s)NC_000018, NG_011803, NC_018929
UniProt ID(s)Q02413
UniGene ID(s)Q02413
HGNC ID(s)3048
Cosmic ID(s)DSG1
KEGG Gene ID(s)hsa:1828
PharmGKB ID(s)PA27501
General Description of Desmoglein-1.
Recognizes a protein of ~150kDa, identified as Desmoglein-1 (DSG1). Desmoglein-1 is a member of the desmosomal cadherin family. Desmosomes are intercellular adhering junctions that represent cell surface attachment sites for intermediate filament. Desmocollins and desmogleins are the main desmosomal transmembrane proteins. Desmogleins consist of Dsg1, Dsg2, Dsg3, and Dsg4 isoforms. Within the desmosome, the extracellular domain of desmoglein is essential for calcium dependent heterophilic binding to the desmocollins, whereas the intracellular domain is essential for binding to the desmosomal plaque protein, plakoglobin. Desmoglein 1 is synthesized exclusively in the suprabasal layers. Intact and functionally active desmoglein 1 is essential to epidermal integrity.

Human Anti-Desmoglein-1 Antibody Product Attributes

Species: Human
Tested Applications: Immunohistochemistry (IHC).
Clonality: Monoclonal
Anti-Desmoglein-1 Antibody Clone: DSG1/1733
Clone DSG1/1733 Host and Isotype: Mouse IgG1 kappa
Anti-Human Desmoglein-1 Positive Control Sample: A431 or A-375 cells. Skin
Cellular Localization of Antibody Cell surface
Buffer and Stabilizer: 10mM PBS with 0.05% BSA and 0.05% Azide
Antibody Concentration: 200 ug/ml
Antibody Purification Method:Protein A/G Purified
Immunogen: Recombinant human desmoglein-1 protein fragment corresponding to intracellular domain
Storage Conditions: Store at 2 to 8° C (refrigerate). Stable for 24 months when properly stored.

Desmoglein-1 Previously Observed Antibody Staining Patterns

Observed Antibody Staining Data By Tissue Type:

Variations in Desmoglein-1 antibody staining intensity in immunohistochemistry on tissue sections are present across different anatomical locations. An intense signal was observed in epidermal cells in the skin, keratinocytes in skin, Langerhans in skin, squamous epithelial cells in the cervix, uterine, oral mucosa and vagina and urothelial cells in the urinary bladder. More moderate antibody staining intensity was present in epidermal cells in the skin, keratinocytes in skin, Langerhans in skin, squamous epithelial cells in the cervix, uterine, oral mucosa and vagina and urothelial cells in the urinary bladder. Low, but measureable presence of Desmoglein-1 could be seen in cells in the tubules in kidney, endothelial cells in the colon, glandular cells in the adrenal gland, breast, cervix, uterine, colon, endometrium, gallbladder, rectum, seminal vesicle and thyroid gland, hepatocytes in liver, melanocytes in skin, respiratory epithelial cells in the nasopharynx, squamous epithelial cells in the tonsil and trophoblastic cells in the placenta. We were unable to detect Desmoglein-1 in other tissues. Disease states, inflammation, and other physiological changes can have a substantial impact on antibody staining patterns. These measurements were all taken in tissues deemed normal or from patients without known disease.

Observed Antibody Staining Data By Tissue Disease Status:

Tissues from cancer patients, for instance, have their own distinct pattern of Desmoglein-1 expression as measured by anti-Desmoglein-1 antibody immunohistochemical staining. The average level of expression by tumor is summarized in the table below. The variability row represents patient to patient variability in IHC staining.

Sample Type breast cancer carcinoid cervical cancer colorectal cancer endometrial cancer glioma head and neck cancer liver cancer lung cancer lymphoma melanoma ovarian cancer pancreatic cancer prostate cancer renal cancer skin cancer stomach cancer testicular cancer thyroid cancer urothelial cancer
Signal Intensity - - - ++ - - - - - - - + - + - + - - + -
DSG1 Variability + ++ + ++ + + ++ ++ ++ + + ++ ++ ++ ++ ++ ++ ++ ++ ++

Limitations and Warranty

enQuire Bio's Desmoglein-1 Anti-Human Monoclonal is available for Research Use Only. This antibody is guaranteed to work for a period of two years when properly stored.

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