Immunohistochemical staining of Elastin  of human FFPE tissue followed by incubation with HRP labeled secondary and development with DAB substrate.

Elastin [BA-4] Antibody (cGMP).

$ 158.00$ 708.00
Please Select Product Options Below To View The Catalog Number.

SKU: QIVD132
Species: Human
Tested Applications: IHC [IVD]
Available Conjugates:
Isotype: Mouse IgG1

Product NumberDescriptionPrice
QIVD132-0.1ml Size: 0.1 ml, Format: Concentrate $ 158.00
QIVD132-0.5ml Size: 0.5 ml, Format: Concentrate $ 288.00
QIVD132-1ml Size: 1 ml, Format: Concentrate $ 488.00
QIVD132-6ml Size: 6 ml, Format: Predilute $ 258.00
QIVD132-25ml Size: 25 ml, Format: Predilute $ 708.00
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Datasheets and Documentation
Product Datasheet
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SKU: QIVD132-0.1ml
Elastin General Information
Alternate Names
Molecular Weight
68.4 kDa
Chromosomal Location
q11.23 [chr: 7] [chr_start: 74027789] [chr_end: 74069907] [strand: 1]
Curated Database and Bioinformatic Data
Gene SymbolELN
Entrez Gene ID2006
RefSeq Protein Accession(s)NP_001075224; NP_001265845; NP_001265868; NP_001075222; NP_001265844; NP_001075223; NP_000492; NP_001075221
RefSeq mRNA Accession(s)XM_011515873; NM_001278914; NM_001278915; NM_001278916; NM_001278918; XM_005250187; XM_011515869; XM_011515874; XM_011515876; NM_001081755; NM_001278912; XM_011515871; NM_000501; NM_001278913; NM_001278939; XM_011515875; NM_001081752; XM_005250188; XM_011515868; XM_011515870; XM_011515872; XM_017011813; XM_017011814; NM_001081753; NM_001081754; XM_011515877; NM_001278917
RefSeq Genomic Accession(s)NC_000007; NG_009261
UniProt ID(s)P15502
PharmGKB ID(s)PA27757
KEGG Gene ID(s)hsa:2006
Associated Diseases (KEGG IDs)Cutis laxa, autosomal dominant, 1 (ADCL1) [MIM:123700]: A connective tissue disorder characterized by loose, hyperextensible skin with decreased resilience and elasticity leading to a premature aged appearance. Face, hands, feet, joints, and torso may be differentially affected. Additional variable clinical features are gastrointestinal diverticula, hernia, and genital prolapse. Rare manifestations are pulmonary artery stenosis, aortic aneurysm, bronchiectasis, and emphysema. {ECO:0000269|PubMed:9873040}. The disease is caused by mutations affecting the gene represented in this entry.; Supravalvular aortic stenosis (SVAS) [MIM:185500]: Congenital narrowing of the ascending aorta which can occur sporadically, as an autosomal dominant condition, or as one component of Williams-Beuren syndrome. {ECO:0000269|PubMed:10942104}. The disease is caused by mutations affecting the gene represented in this entry.; ELN is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region. Haploinsufficiency of ELN may be the cause of certain cardiovascular and musculo-skeletal abnormalities observed in the disease (PubMed:8812460). {ECO:0000269|PubMed:8812460}.
General Description of Elastin .
This antibody recognizes insoluble elastin, alpha-elastin, soluble non-cross linked precursor of elastin (tropoelastin). Elastin is an important polymeric protein of connective tissue that imparts elasticity to vertebrate elastic tissues.

Antibody (Suitable for clinical applications)

Sample Type: FFPE Patient Samples.
Tested Applications: IHC. Approved for In Vitro Diagnostic Procedures on FFPE tissues. For tissue collection recommendations, please see datasheet sent with product.
Application Notes
Specification Recommendation
Recommended Dilution (Conc) 1:50-1:100
Pretreatment HistoZyme
Incubation Parameters 30 min at Room Temperature

Prior to use, inspect vial for the presence of any precipitate or other unusual physical properties. These can indicate that the antibody has degraded and is no longer suitable for patient samples. Please run positive and negative controls simultaneously with all patient samples to account and control for errors in laboratory procedure. Use of methods or materials not recommended by enQuire Bio including change to dilution range and detection system should be routinely validated by the user.

Clonality: Monoclonal
Anti-Elastin Antibody Clone: BA-4
Host and Isotype: Mouse IgG1
Recommended Positive Control Sample: Heart, Kidney
Cellular Localization of Antibody BA-4 Staining: Connective tissue
Buffer and Stabilizer: PBS with 1% BSA and 0.05% NaN3
Antibody Concentration: Lot specific. Plese contact tech support for data.
Immunogen: Bovine alpha-elastin.
Storage Conditions: This antibody should be stored refrigerated (2-8°C). This product should not be used past the expiration date printed on the vial.

Elastin Information for Pathologists

Summary:

Elastin is found in connective tissue and is responsible for elasticity of soft tissue. It is heavily modified post-synthesis prior to being incorporated into elastic fibers in the extracellular space. Accumulation of elastin is common in diseases such as athersclerosis where increased staining is observed in blood vessels.

Limitations and Warranty

This antibody is manufactured in accordance with clinical good manufacturing practices in an ISO13485:2016 certified production facility. It is intended for multiple uses including in vitro diagnostic use and research use only applications. Please see vial label for expiration date. We strive to always deliver antibodies with a shelf life of at least two years.

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Elastin [BA-4] Antibody (cGMP).