Immunohistochemical staining of Factor XIII-A  of human FFPE tissue followed by incubation with HRP labeled secondary and development with DAB substrate.

Factor XIII-A [Polyclonal] Antibody (cGMP).

$ 135.00$ 415.00
Please Select Product Options Below To View The Catalog Number.

SKU: QIVD126
Species: Human
Tested Applications: IHC [IVD]
Available Conjugates:
Isotype: Rabbit Undetermined

Product NumberDescriptionPrice
QIVD126-0.1ml Size: 0.1 ml, Format: Concentrate $ 135.00
QIVD126-0.5ml Size: 0.5 ml, Format: Concentrate $ 245.00
QIVD126-1ml Size: 1 ml, Format: Concentrate $ 415.00
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Datasheets and Documentation
Product Datasheet
Certificate of Analysis and Tags (Coming Soon)
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SKU: QIVD126-0.1ml
Factor XIII-A General Information
Alternate Names
Molecular Weight
83.3 kDa
Chromosomal Location
p25.1 [chr: 6] [chr_start: 6144085] [chr_end: 6321013] [strand: -1]
Curated Database and Bioinformatic Data
Gene SymbolF13A1
Entrez Gene ID2162
RefSeq Protein Accession(s)NP_000120
RefSeq mRNA Accession(s); NM_000129
RefSeq Genomic Accession(s)NC_000006; NG_008107
UniProt ID(s)P00488
PharmGKB ID(s)PA162
KEGG Gene ID(s)hsa:2162
Associated Diseases (KEGG IDs)Factor XIII subunit A deficiency (FA13AD) [MIM:613225]: An autosomal recessive hematologic disorder characterized by a life-long bleeding tendency, impaired wound healing and spontaneous abortion in affected women. {ECO:0000269|PubMed:1353995, ECO:0000269|PubMed:20179087, ECO:0000269|PubMed:24286209, ECO:0000269|PubMed:24329762, ECO:0000269|PubMed:24889649, ECO:0000269|PubMed:27363989}. The disease is caused by mutations affecting the gene represented in this entry.
General Description of Factor XIII-A .
This antibody reacts with a 160 kDa (unreacted dimer) and 80 kDa (reduced monomer) protein. Factor XIII is a beta-globulin found in plasma and is composed of two subunits, Factor XIII-A and Factor XIII-B. Factor XIII-A is the catalytic subunit and is a dimer of M.W. 160 kDa. Factor XIII is a dermal dendrocyte marker and shows variable reaction with these types of tumors. Factor XIII can be used for histiocytic phenotyping and has been reported to mark capillary hemangiomas and tumors of the central nervous system.

Antibody (Suitable for clinical applications)

Sample Type: FFPE Patient Samples.
Tested Applications: IHC. Approved for In Vitro Diagnostic Procedures on FFPE tissues. For tissue collection recommendations, please see datasheet sent with product.
Application Notes
Specification Recommendation
Recommended Dilution (Conc) 1:25-1:50
Pretreatment Citrate Buffer pH 6.0
Incubation Parameters 30 min at Room Temperature

Prior to use, inspect vial for the presence of any precipitate or other unusual physical properties. These can indicate that the antibody has degraded and is no longer suitable for patient samples. Please run positive and negative controls simultaneously with all patient samples to account and control for errors in laboratory procedure. Use of methods or materials not recommended by enQuire Bio including change to dilution range and detection system should be routinely validated by the user.

Clonality: Polyclonal
Anti-Factor XIII-A Antibody Clone: Polyclonal
Host and Isotype: Rabbit Undetermined
Recommended Positive Control Sample: Placenta
Cellular Localization of Antibody Polyclonal Staining: Cytoplasmic, nuclear
Buffer and Stabilizer: PBS with 1% BSA and 0.05% NaN3
Antibody Concentration: Lot specific. Plese contact tech support for data.
Immunogen: Recombinant protein corresponding to A-subunit of coagulation Factor XIII a.
Storage Conditions: This antibody should be stored refrigerated (2-8°C). This product should not be used past the expiration date printed on the vial.

Factor XIII-A Information for Pathologists

Summary:

Fibrohistiocytic marker; note that peritumoral cells may also exhibit Factor XIIIa staining. Also active form of factor XIII, an enzyme of coagulation system that crosslinks fibrin (Wikipedia: Factor XIII [Accessed 2 August 2018]). Uses by pathologists Marker of fibrohistiocytic proliferations. Marker of dermal dencrocytes.

Common Uses By Pathologists:

Marker of fibrohistiocytic proliferations. Marker of dermal dencrocytes. Differentiate dermatofibrosarcoma protuberans (CD34+, D2-40-, Factor XIIIa-) from dermatofibroma (CD34-, Factor XIIIa+, D2-40+). Microscopic (histologic) images Images hosted on PathOut server:.

Limitations and Warranty

This antibody is manufactured in accordance with clinical good manufacturing practices in an ISO13485:2016 certified production facility. It is intended for multiple uses including in vitro diagnostic use and research use only applications. Please see vial label for expiration date. We strive to always deliver antibodies with a shelf life of at least two years.

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Factor XIII-A [Polyclonal] Antibody (cGMP).