Human Anti-GARP Antibody [GARP5]

$ 149.00$ 329.00
Please Select A Product To View The SKU.

SKU: QAB84
Species: Human
Tested Applications: Flow Cytometry
Available Conjugates: APC ;PE
Isotype: Mouse IgG1
Mass Spec Validated?: Not MS Validated

Size
Tag Clear selection
Shipping Information
In Stock: 1-2 Day Lead Time.
Flat Rate Shipping Anywhere in the US: $45
Datasheets and Documentation
Product Datasheet
SKU: QAB84-APC-25Tests
GARP General Information
Alternate Names
LRRC32, Latent TGF beta receptor
Curated Database and Bioinformatic Data
Gene SymbolLRRC32
Entrez Gene ID2615
Ensemble Gene IDENSG00000137507
RefSeq Protein Accession(s)NP_001122394, XP_011543237, XP_005273960, NP_005503, XP_005273959, XP_016873016
RefSeq mRNA Accession(s)XM_005273903, XM_005273902, XM_011544935, NM_001128922, NM_005512, XM_017017527
RefSeq Genomic Accession(s)NC_000011, NC_018922
UniProt ID(s)Q14392, A0A024R5J7
UniGene ID(s)Q14392, A0A024R5J7
HGNC ID(s)4161
Cosmic ID(s)LRRC32
KEGG Gene ID(s)hsa:2615
PharmGKB ID(s)PA28574
General Description of GARP.
The GARP5 antibody reacts with human GARP, also known as LRRC32 or Garpin, an 80 kDa transmembrane protein which acts as a receptor for the latent form of TGF-beta 1 (pro-TGF-beta), preventing its secretion. Specifically, GARP is reported to associate with the pro-domain of TGF-beta 1, known as latency-associated peptide (LAP), which must be cleaved to release the biologically active cytokine. The putative role of GARP in sequestering the TGF-beta is important for regulating its activity, as TGF-beta signaling is involved in development and function of Th17, Treg and many other immune cell types. GARP expression has been shown on platelets and at high levels on Foxp3+ Treg cells, where it is proposed to be a phenotypic identifier for activated human Treg cells.The GARP5 antibody may be used for analysis of human GARP by flow cytometry, immunoprecipitation and Western Blot.

Human Anti-GARP Antibody Product Attributes

Species: Human
Tested Applications: Flow Cytometry.
Application Notes: 5 ul per test where one test represents staining of a cell sample in a final volume of approximately 100 uL. The number of cells within a sample must be experimentally determined, but ranges between 1x105 to 1x108 cells.
Clonality: Monoclonal Antibody
Anti-GARP Antibody Clone: GARP5
Clone GARP5 Host and Isotype: Mouse IgG1
Buffer and Stabilizer: 10 mM NaH2PO4, 150 mM NaCl, 0.09% NaN3, 0.1% gelatin, pH7.2
Antibody Concentration: 5 uL /test
Storage Conditions: 2-8C protected from light. Stable for 12 Months. Do Not Freeze.

GARP Previously Observed Antibody Staining Patterns

Selected References

Wang I, Zhu J, Dong X, Shi M, Lu C, and Springer TA. 2012. Mol. Biol. Cell. 23: 1129 - 1139. (Flow cytometry, Immunoprecipitation, Western blot).

Limitations and Warranty

enQuire Bio's Human Anti-GARP Monoclonal is available for Research Use Only. This antibody is guaranteed to work for a period of two years when properly stored.

There are no reviews yet.

Be the first to review “Human Anti-GARP Antibody [GARP5]”

Your email address will not be published. Required fields are marked *

Share a Protocol (View Reviewed Protocols Below)

Protocol Title

Materials

Methods

Notes


  protocol submission gif

enQuire Bio, LLC   1825 Lawrence St, Ste 115   Denver, CO 80202
Phone: 1-855-344-1400 | enquire@enquirebio.com | Fax: 1-855-344-1400
Customer Service Available M-F 8AM-6PM MST or 24/7 Via Email
Scroll to top