Staining by anti-Growth Hormone Antibody 1

Anti-Growth Hormone Antibody Clone GH/1371

$ 118.00$ 418.00
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SKU: 2688-MSM1
Species: Human
Tested Applications: Immunohistochemistry (IHC)
Available Conjugates: Unconjugated
Isotype: Mouse IgG2b
Mass Spec Validated?: Not MS Validated

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Datasheets and Documentation
Product Datasheet
SKU: 2688-MSM1-P0
Growth Hormone General Information
Alternate Names
GH1, GH, Pituitary Growth Hormone, Growth Hormone, Somatotropin
Molecular Weight
20kDa
Chromosomal Location
17q24.2
Curated Database and Bioinformatic Data
Gene SymbolGH1
Entrez Gene ID2688
Ensemble Gene IDENSG00000259384
RefSeq Protein Accession(s)NP_072054, NP_000506, NP_072053
RefSeq mRNA Accession(s)NM_022559, NM_000515, NM_022560, NM_022561, NM_022562
RefSeq Genomic Accession(s)NC_000017, NC_018928, NG_011676
UniProt ID(s)B1A4G7, P01241, B1A4G6
UniGene ID(s)B1A4G7, P01241, B1A4G6
HGNC ID(s)4261
Cosmic ID(s)GH1
KEGG Gene ID(s)hsa:2688
PharmGKB ID(s)PA171
General Description of Growth Hormone.
Pituitary growth hormone (GH) plays a crucial role in stimulating and controlling the growth, metabolism and differentiation of many mammalian cell types by modulating the synthesis of multiple mRNA species. These effects are mediated by the binding of GH to its membrane-bound receptor, GHR, and involve a phosphorylation cascade that results in the modulation of numerous signaling pathways. GH is synthesized by acidophilic or somatotropic cells of the anterior pituitary gland. Anti-GH is a useful marker in classification of pituitary tumors and the study of pituitary disease (acromegaly).

Human Anti-Growth Hormone Antibody Product Attributes

Species: Human
Tested Applications: Immunohistochemistry (IHC).
Clonality: Monoclonal
Anti-Growth Hormone Antibody Clone: GH/1371
Clone GH/1371 Host and Isotype: Mouse IgG2b
Anti-Human Growth Hormone Positive Control Sample: Pituitary cells or Pituitary
Cellular Localization of Antibody Cytoplasmic
Buffer and Stabilizer: 10mM PBS with 0.05% BSA and 0.05% Azide
Antibody Concentration: 200 ug/ml
Antibody Purification Method:Protein A/G Purified
Immunogen: A recombinant human Growth Hormone (GH) fragment (aa58-187)
Storage Conditions: Store at 2 to 8° C (refrigerate). Stable for 24 months when properly stored.

Growth Hormone Previously Observed Antibody Staining Patterns

Observed Antibody Staining Data By Tissue Type:

Variations in Growth Hormone antibody staining intensity in immunohistochemistry on tissue sections are present across different anatomical locations. An intense signal was observed in cells in the anterior in pituitary gland and trophoblastic cells in the placenta. More moderate antibody staining intensity was present in cells in the anterior in pituitary gland and trophoblastic cells in the placenta. Low, but measureable presence of Growth Hormone could be seen in. We were unable to detect Growth Hormone in other tissues. Disease states, inflammation, and other physiological changes can have a substantial impact on antibody staining patterns. These measurements were all taken in tissues deemed normal or from patients without known disease.

Limitations and Warranty

enQuire Bio's Growth Hormone Anti-Human Monoclonal is available for Research Use Only. This antibody is guaranteed to work for a period of two years when properly stored.

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Anti-Growth Hormone Antibody Clone GH/1371