Formalin-fixed, paraffin-embedded human Tonsil stained with Involucrin Monoclonal Antibody (IVRN/827)
Formalin-fixed, paraffin-embedded human Tonsil stained with Involucrin Monoclonal Antibody (IVRN/827)

Anti-Involucrin Antibody Clone IVRN/827

$ 429.00
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SKU: 3713-MSM2
Species: Human
Tested Applications: Flow Cytometry, Immunofluorescence, Immunohistochemistry (IHC)
Available Conjugates: Unconjugated
Isotype: Mouse IgG1 kappa
Mass Spec Validated?: Not MS Validated

Product NumberDescriptionPrice
3713-MSM2-P1 Size: 100 ug, Tag: Unconjugated
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SKU: 3713-MSM2-P1
Involucrin General Information
Alternate Names
Involucrin, IVL
Molecular Weight
Chromosomal Location
Curated Database and Bioinformatic Data
Gene SymbolIVL
Entrez Gene ID3713
Ensemble Gene IDENSG00000163207
RefSeq Protein Accession(s)NP_005538
RefSeq mRNA Accession(s)NM_005547
RefSeq Genomic Accession(s)NC_000001, NG_033018, NC_018912
UniProt ID(s)P07476
UniGene ID(s)P07476
HGNC ID(s)6187
Cosmic ID(s)IVL
KEGG Gene ID(s)hsa:3713
PharmGKB ID(s)PA29985
General Description of Involucrin.
It recognizes a protein of 66kDa-170kDa, identified as involucrin. In Western Blot of cultured human keratinocytes, this MAb reacts with a 120kDa protein. Involucrin is expressed in a range of stratified squamous epithelia, including the cornea, which lacks a distinct cornified layer. In normal epidermis, it is first expressed in the upper spinous layers,, in keratinocyte cultures, all cells that have left the basal layer express it. Involucrin expression is altered in pathological conditions: in psoriasis, other benign epidermal hyperplasias, involucrin expression begins closer to the basal layer than normal; expression is abnormal in squamous cell carcinomas, premalignant lesions,, is reduced in severe dysplasias of the larynx, cervix.

Human Anti-Involucrin Antibody Product Attributes

Species: Human
Tested Applications: Flow Cytometry, Immunofluorescence, Immunohistochemistry (IHC).
Application Notes: Flow Cytometry (0.5-1ug of antibody/million cells in 0.1ml), Immunofluorescence (1-2ug of antibody/ml), Immunohistochemistry (IHC) (Formalin-fixed) (0.1-0.2ug of antibody/ml for 30 min at RT)
Clonality: Monoclonal
Anti-Involucrin Antibody Clone: IVRN/827
Clone IVRN/827 Host and Isotype: Mouse IgG1 kappa
Anti-Human Involucrin Positive Control Sample: MCF-7 cells. Localized to upper spinous, granular layers in normal skin.
Cellular Localization of Antibody Cytoplasmic
Buffer and Stabilizer: 10mM PBS with 0.05% BSA & 0.05% azide.
Antibody Concentration: 200ug/ml
Antibody Purification Method:Protein A/G Purified
Immunogen: Purified involucrin from human keratinocytes
Storage Conditions: Store at 2 to 8° C (refrigerate). Stable for 24 months when properly stored.

Involucrin Previously Observed Antibody Staining Patterns

Observed Subcellular, Organelle Specific Staining Data:

Anti-IVL antibody staining is expected to be primarily localized to the cytosol, centrosome and nuclear bodies. There is variability in either the signal strength or the localization of signal in cytosol from cell to cell.

Observed Antibody Staining Data By Tissue Type:

Variations in Involucrin antibody staining intensity in immunohistochemistry on tissue sections are present across different anatomical locations. An intense signal was observed in squamous epithelial cells in the oral mucosa, vagina. More moderate antibody staining intensity was present in squamous epithelial cells in the oral mucosa, vagina. Low, but measureable presence of Involucrin could be seen in. We were unable to detect Involucrin in other tissues. Disease states, inflammation, and other physiological changes can have a substantial impact on antibody staining patterns. These measurements were all taken in tissues deemed normal or from patients without known disease.

Observed Antibody Staining Data By Tissue Disease Status:

Tissues from cancer patients, for instance, have their own distinct pattern of Involucrin expression as measured by anti-Involucrin antibody immunohistochemical staining. The average level of expression by tumor is summarized in the table below. The variability row represents patient to patient variability in IHC staining.

Sample Type breast cancer carcinoid cervical cancer colorectal cancer endometrial cancer glioma head and neck cancer liver cancer lung cancer lymphoma melanoma ovarian cancer pancreatic cancer prostate cancer renal cancer skin cancer stomach cancer testicular cancer thyroid cancer urothelial cancer
Signal Intensity - - - - - - - - - - - - - - - + - - - ++
IVL Variability + + ++ + + + ++ + ++ + + + + + + +++ + + + ++

Limitations and Warranty

enQuire Bio's Involucrin Anti-Human Monoclonal is available for Research Use Only. This antibody is guaranteed to work for a period of two years when properly stored.

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Anti-Involucrin Antibody Clone IVRN/827