Formalin-fixed, paraffin-embedded Human Melanoma stained with MART-1 Recombinant Rabbit Monoclonal Antibody (MLANA/149R).
Formalin-fixed, paraffin-embedded Human Melanoma stained with MART-1 Recombinant Rabbit Monoclonal Antibody (MLANA/149R).

Anti-MART-1 / MLANA Antibody Clone MLANA/1409R

$ 178.00$ 498.00
Please Select Product Options Below To View The Catalog Number.

SKU: 2315-RBM9
Species: Human, Mouse, and Rat
Tested Applications: Immunohistochemistry (IHC)
Available Conjugates: Unconjugated
Isotype: Rabbit IgG kappa
Mass Spec Validated?: Not MS Validated

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Datasheets and Documentation
Product Datasheet
SKU: 2315-RBM9-P0
MART-1 / MLANA General Information
Alternate Names
Protein melan-A melanoma antigen recognized by T cells 1, MART-1, MLANA
Molecular Weight
20-22kDa (doublet)
Chromosomal Location
9p24.1
Curated Database and Bioinformatic Data
Gene SymbolMLANA
Entrez Gene ID2315
Ensemble Gene IDENSG00000120215
RefSeq Protein Accession(s)NP_005502
RefSeq mRNA Accession(s)NM_005511
RefSeq Genomic Accession(s)NC_018920, NC_000009
UniProt ID(s)Q16655
UniGene ID(s)Q16655
HGNC ID(s)7124
Cosmic ID(s)MLANA
KEGG Gene ID(s)hsa:2315
PharmGKB ID(s)PA30842
General Description of MART-1 / MLANA.
This antibody recognizes a protein doublet of 20-22kDa, identified as MART-1 (Melanoma Antigen Recognized by T cells 1) or Melan-A. MART-1 is a newly identified melanocyte differentiation antigen recognized by autologous cytotoxic T lymphocytes. Seven other melanoma associated antigens recognized by autologous cytotoxic T cells include MAGE-1, MAGE-3, tyrosinase, gp100, gp75, BAGE-1, and GAGE-1. Subcellular fractionation shows that MART-1 is present in melanosomes and endoplasmic reticulum. This MAb labels melanomas and other tumors showing melanocytic differentiation. It is also a useful positive-marker for angiomyolipomas. It does not stain tumor cells of epithelial, lymphoid, glial, or mesenchymal origin.

Human, Mouse, and Rat Anti-MART-1 / MLANA Antibody Product Attributes

Species: Human, Mouse, and Rat
Tested Applications: Immunohistochemistry (IHC).
Clonality: Recombinant Monoclonal
Anti-MART-1 / MLANA Antibody Clone: MLANA/1409R
Clone MLANA/1409R Host and Isotype: Rabbit IgG kappa
Anti-Human, Mouse, and Rat MART-1 / MLANA Positive Control Sample: SK-MEL-13 and SK-MEL-19 Melanoma cell lines; Melanomas
Cellular Localization of Antibody Cytoplasmic
Buffer and Stabilizer: 10mM PBS with or without 0.05% BSA & 0.05% azide.
Antibody Concentration: 200ug/ml
Antibody Purification Method:Protein A/G Purified
Immunogen: Recombinant human full-length MLANA protein
Storage Conditions: Store at 2 to 8° C (refrigerate). Stable for 24 months when properly stored.

MART-1 / MLANA Previously Observed Antibody Staining Patterns

Observed Antibody Staining Data By Tissue Type:

Variations in MART-1 / MLANA antibody staining intensity in immunohistochemistry on tissue sections are present across different anatomical locations. An intense signal was observed in melanocytes in skin. More moderate antibody staining intensity was present in melanocytes in skin. Low, but measureable presence of MART-1 / MLANA could be seen in. We were unable to detect MART-1 / MLANA in other tissues. Disease states, inflammation, and other physiological changes can have a substantial impact on antibody staining patterns. These measurements were all taken in tissues deemed normal or from patients without known disease.

Limitations and Warranty

enQuire Bio's MART-1 / MLANA Recombinant Monoclonal is available for Research Use Only. This antibody is guaranteed to work for a period of two years when properly stored.

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