Formalin-fixed, paraffin-embedded human Gastric Carcinoma stained with MUC6 Monoclonal Antibody (SPM598).
Formalin-fixed, paraffin-embedded human Gastric Carcinoma stained with MUC6 Monoclonal Antibody (SPM598).

Anti-MUC6 Antibody Clone SPM598

$ 298.00
Please Select Product Options Below To View The Catalog Number.

SKU: 4588-MSM1X
Species: Human
Tested Applications: Flow Cytometry, Immunofluorescence, Immunohistochemistry (IHC)
Available Conjugates: Unconjugated
Isotype: Mouse IgG1 kappa
Mass Spec Validated?: Not MS Validated

Product NumberDescriptionPrice
4588-MSM1X-P1 Size: 100 ug, Tag: Unconjugated
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SKU: 4588-MSM1X-P1
MUC6 General Information
Alternate Names
Mucin 6, oligomeric mucus/gel-forming MUC6
Molecular Weight
252kDa
Chromosomal Location
11p15.5
Curated Database and Bioinformatic Data
Gene SymbolMUC6
Entrez Gene ID4588
Ensemble Gene IDENSG00000283350, ENSG00000277281, ENSG00000184956, ENSG00000277518
RefSeq Protein Accession(s)NP_005952
RefSeq mRNA Accession(s)NM_005961
RefSeq Genomic Accession(s)NG_052845, NW_015148966, NC_018922, NG_187681, NC_000011, NG_187656
UniProt ID(s)Q6W4X9
UniGene ID(s)Q6W4X9
HGNC ID(s)7517
Cosmic ID(s)MUC6
KEGG Gene ID(s)hsa:4588
General Description of MUC6.
The MUC6 gastric mucin is a secreted glycoprotein that plays an essential role in epithelial cyto-protection from acid, proteases, pathogenic microorganisms,, mechanical trauma in the gastrointestinal tract. Mucin 6 expression is highest in the stomach, gall bladder, with lower expression in the terminal ileum, right colon. In gastric cancer, Mucin 6 has an altered expression. In normal stomach, Mucin 6 is associated with Lewis type 2; Mucin 6 is also expressed in gastric metaplasia, duodenum, pancreas. Mucin 6 is a secretory mucin, located in the deeper mucosal folds of human gall bladder,, its expression is altered with increasing degrees of inflammation.

Human Anti-MUC6 Antibody Product Attributes

Species: Human
Tested Applications: Flow Cytometry, Immunofluorescence, Immunohistochemistry (IHC).
Application Notes: Flow Cytometry (0.5-1ug of antibody/million cells in 0.1ml), Immunofluorescence (1-2ug of antibody/ml), Immunohistochemistry (IHC) (Formalin-fixed) (2-4ug of antibody/ml for 30 minutes at RT)
Clonality: Monoclonal
Anti-MUC6 Antibody Clone: SPM598
Clone SPM598 Host and Isotype: Mouse IgG1 kappa
Anti-Human MUC6 Positive Control Sample: Stomach
Cellular Localization of Antibody Cytoplasmic & Secreted
Buffer and Stabilizer: 10mM PBS with 0.05% BSA & 0.05% azide.
Antibody Concentration: 200ug/ml
Antibody Purification Method:Protein A/G Purified
Immunogen: A synthetic peptide of the Gastric Mucin 6 tandem repeat sequence
Storage Conditions: Store at 2 to 8° C (refrigerate). Stable for 24 months when properly stored.

MUC6 Previously Observed Antibody Staining Patterns

Observed Antibody Staining Data By Tissue Type:

Variations in MUC6 antibody staining intensity in immunohistochemistry on tissue sections are present across different anatomical locations. An intense signal was observed in glandular cells in the seminal vesicle, stomach. More moderate antibody staining intensity was present in glandular cells in the seminal vesicle, stomach. Low, but measureable presence of MUC6 could be seen inglandular cells in the duodenum, exocrine glandular cells in the pancreas and islets of Langerhans in pancreas. We were unable to detect MUC6 in other tissues. Disease states, inflammation, and other physiological changes can have a substantial impact on antibody staining patterns. These measurements were all taken in tissues deemed normal or from patients without known disease.

Observed Antibody Staining Data By Tissue Disease Status:

Tissues from cancer patients, for instance, have their own distinct pattern of MUC6 expression as measured by anti-MUC6 antibody immunohistochemical staining. The average level of expression by tumor is summarized in the table below. The variability row represents patient to patient variability in IHC staining.

Sample Type breast cancer carcinoid cervical cancer colorectal cancer endometrial cancer glioma head and neck cancer liver cancer lung cancer lymphoma melanoma ovarian cancer pancreatic cancer prostate cancer renal cancer skin cancer stomach cancer testicular cancer thyroid cancer urothelial cancer
Signal Intensity - - - - - - - - - - - - - - - - - - - -
MUC6 Variability + + + + ++ + + + + + + + ++ ++ + + ++ + + +

Limitations and Warranty

enQuire Bio's MUC6 Anti-Human Monoclonal is available for Research Use Only. This antibody is guaranteed to work for a period of two years when properly stored.

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Anti-MUC6 Antibody Clone SPM598

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