Immunohistochemical staining of Myelin Basic Protein  of human FFPE tissue followed by incubation with HRP labeled secondary and development with DAB substrate.

Myelin Basic Protein [Polyclonal] Antibody (cGMP).

$ 158.00$ 1,048.00
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SKU: QIVD159
Species: Human
Tested Applications: IHC [IVD]
Available Conjugates:
Isotype: Rabbit Undetermined

Product NumberDescriptionPrice
QIVD159-0.1ml Size: 0.1 ml, Format: Concentrate $ 135.00
QIVD159-0.5ml Size: 0.5 ml, Format: Concentrate $ 575.00
QIVD159-1ml Size: 1 ml, Format: Concentrate $ 935.00
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Datasheets and Documentation
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SKU: QIVD159-0.1ml
Myelin Basic Protein General Information
Alternate Names
Molecular Weight
33.1 kDa
Chromosomal Location
q23 [chr: 18] [chr_start: 76978827] [chr_end: 77133683] [strand: -1]
Curated Database and Bioinformatic Data
Gene SymbolMBP
Entrez Gene ID4155
RefSeq Protein Accession(s)NP_001020263; NP_002376; NP_001020252; NP_001020271; XP_016881269; NP_001020261; NP_001020272
RefSeq mRNA Accession(s)NM_001025081; XM_024451185; XM_024451186; XM_024451188; XR_001753201; NM_002385; NM_001025090; NM_001025094; XM_024451187; XR_001753202; XM_017025778; NM_001025092; NM_001025101; XM_017025780; XM_024451189; NM_001025100; NM_001025098
RefSeq Genomic Accession(s); NC_000018
UniProt ID(s)P02686
PharmGKB ID(s)PA30667
KEGG Gene ID(s)hsa:4155
Associated Diseases (KEGG IDs)The reduction in the surface charge of citrullinated and/or methylated MBP could result in a weakened attachment to the myelin membrane. This mechanism could be operative in demyelinating diseases such as chronical multiple sclerosis (MS), and fulminating MS (Marburg disease).
General Description of Myelin Basic Protein .
This antibody reacts with human myelin basic protein and oligodendrocytes of white matter in brain and spinal cord. Grey matter stains weakly. This antibody stains peripheral nerves also.

Antibody (Suitable for clinical applications)

Sample Type: FFPE Patient Samples.
Tested Applications: IHC. Approved for In Vitro Diagnostic Procedures on FFPE tissues. For tissue collection recommendations, please see datasheet sent with product.
Application Notes
Specification Recommendation
Recommended Dilution (Conc) 1:20-1:40
Pretreatment No Pretreatment Required
Incubation Parameters 30 min at Room Temperature

Prior to use, inspect vial for the presence of any precipitate or other unusual physical properties. These can indicate that the antibody has degraded and is no longer suitable for patient samples. Please run positive and negative controls simultaneously with all patient samples to account and control for errors in laboratory procedure. Use of methods or materials not recommended by enQuire Bio including change to dilution range and detection system should be routinely validated by the user.

Clonality: Polyclonal
Anti-Myelin Basic Protein Antibody Clone: Polyclonal
Host and Isotype: Rabbit Undetermined
Recommended Positive Control Sample: Brain
Cellular Localization of Antibody Polyclonal Staining: Cytoplasmic
Buffer and Stabilizer: PBS with 1% BSA and 0.05% NaN3
Antibody Concentration: Lot specific. Plese contact tech support for data.
Immunogen: Human myelin basic protein isolated from normal human brain.
Storage Conditions: This antibody should be stored refrigerated (2-8°C). This product should not be used past the expiration date printed on the vial.

Myelin Basic Protein Information for Pathologists

Summary:

MBP is important in myelination of nerves (reported in both central and peripheral nerves). Myelination of nerves and the formation of the myelin sheath is critical to rapid conduction of neural impulses along axons. Several studies have suggested that auto antibodies against MBP are linked to development of multiple sclerosis (MS).

Notable Clinical Features:

Myelin Basic protein in CSF above levels of 4 ng/ml is indicative myelin breakdown which is linked to MS. MBP staining is reported as a sensitive marker of myelenation.

Common Uses By Pathologists:

Neuromas, Neurofi bromas, and Neurogenic Sarcomas have been reported as staining postive for MBP. However, other spindle-cell neoplasms are typically negative. MBP staining of Granular-cell tumors is useful in supportinga Schwann-cell derivation of these lesions. Unlike other nervous system proteins such as GFAP and S-100, MBP has not been demonstrated in melanocytes or tumors derived from melanocytes.

Limitations and Warranty

This antibody is manufactured in accordance with clinical good manufacturing practices in an ISO13485:2016 certified production facility. It is intended for multiple uses including in vitro diagnostic use and research use only applications. Please see vial label for expiration date. We strive to always deliver antibodies with a shelf life of at least two years.

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Myelin Basic Protein [Polyclonal] Antibody (cGMP).