Antibody (Suitable for clinical applications)
| Specification | Recommendation |
|---|---|
| Recommended Dilution (Conc) | 1:25-1:50 |
| Pretreatment | Citrate Buffer pH 6.0 |
| Incubation Parameters | 30 min at Room Temperature |
Prior to use, inspect vial for the presence of any precipitate or other unusual physical properties. These can indicate that the antibody has degraded and is no longer suitable for patient samples. Please run positive and negative controls simultaneously with all patient samples to account and control for errors in laboratory procedure. Use of methods or materials not recommended by enQuire Bio including change to dilution range and detection system should be routinely validated by the user.
Myeloperoxidase Information for Pathologists
Summary:
Staining is either immunohistochemistry (IHC) or enzyme cytochemistry – enzyme cytochemistry is most sensitive and specific stain for myeloid leukemias and granulocytic sarcoma. Stains neutrophils strongly (diffuse granular pattern), other granulocytes variably. Microscopic (histologic) images Missing Image. Myeloid sarcoma of breast.
| Myeloperoxidase General Information | |
|---|---|
| Alternate Names | |
| Molecular Weight | |
| 83.9 kDa | |
| Chromosomal Location | |
| q22 [chr: 17] [chr_start: 58269856] [chr_end: 58280935] [strand: -1] | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | MPO |
| Entrez Gene ID | 4353 |
| RefSeq Protein Accession(s) | NP_000241 |
| RefSeq mRNA Accession(s) | NM_000250; |
| RefSeq Genomic Accession(s) | NG_009629; NC_000017 |
| UniProt ID(s) | P05164 |
| PharmGKB ID(s) | PA243 |
| KEGG Gene ID(s) | hsa:4353 |
| Associated Diseases (KEGG IDs) | Myeloperoxidase deficiency (MPOD) [MIM:254600]: A disorder characterized by decreased myeloperoxidase activity in neutrophils and monocytes that results in disseminated candidiasis. {ECO:0000269|PubMed:7904599, ECO:0000269|PubMed:8142659, ECO:0000269|PubMed:8621627, ECO:0000269|PubMed:9354683, ECO:0000269|PubMed:9637725}. The disease is caused by mutations affecting the gene represented in this entry. |
| General Description of Myeloperoxidase . | |
| Myeloperoxidase metabolizes most of the hydrogen peroxide generated by activated phagocytes. This antibody stains strongly with the cytoplasm of myeloid cells. The antibody detects myeloperoxidase found in myeloid cells of acute myeloid leukemia. The myeloperoxidase gene has been localized to chromosome 17. | |
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