Immunohistochemical staining of Myeloperoxidase  of human FFPE tissue followed by incubation with HRP labeled secondary and development with DAB substrate.

Myeloperoxidase [59A5] Antibody (cGMP).

$ 135.00$ 465.00
Please Select Product Options Below To View The Catalog Number.

SKU: QIVD160
Species: Human
Tested Applications: IHC [IVD]
Available Conjugates:
Isotype: Mouse IgG2b, kappa

Product NumberDescriptionPrice
QIVD160-0.1ml Size: 0.1 ml, Format: Concentrate $ 135.00
QIVD160-0.5ml Size: 0.5 ml, Format: Concentrate $ 275.00
QIVD160-1ml Size: 1 ml, Format: Concentrate $ 465.00
QIVD160-6ml Size: 6 ml, Format: Predilute $ 255.00
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Datasheets and Documentation
Product Datasheet
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SKU: QIVD160-0.1ml
Myeloperoxidase General Information
Alternate Names
Molecular Weight
83.9 kDa
Chromosomal Location
q22 [chr: 17] [chr_start: 58269856] [chr_end: 58280935] [strand: -1]
Curated Database and Bioinformatic Data
Gene SymbolMPO
Entrez Gene ID4353
RefSeq Protein Accession(s)NP_000241
RefSeq mRNA Accession(s)NM_000250;
RefSeq Genomic Accession(s)NG_009629; NC_000017
UniProt ID(s)P05164
PharmGKB ID(s)PA243
KEGG Gene ID(s)hsa:4353
Associated Diseases (KEGG IDs)Myeloperoxidase deficiency (MPOD) [MIM:254600]: A disorder characterized by decreased myeloperoxidase activity in neutrophils and monocytes that results in disseminated candidiasis. {ECO:0000269|PubMed:7904599, ECO:0000269|PubMed:8142659, ECO:0000269|PubMed:8621627, ECO:0000269|PubMed:9354683, ECO:0000269|PubMed:9637725}. The disease is caused by mutations affecting the gene represented in this entry.
General Description of Myeloperoxidase .
Myeloperoxidase metabolizes most of the hydrogen peroxide generated by activated phagocytes. This antibody stains strongly with the cytoplasm of myeloid cells. The antibody detects myeloperoxidase found in myeloid cells of acute myeloid leukemia. The myeloperoxidase gene has been localized to chromosome 17.

Antibody (Suitable for clinical applications)

Sample Type: FFPE Patient Samples.
Tested Applications: IHC. Approved for In Vitro Diagnostic Procedures on FFPE tissues. For tissue collection recommendations, please see datasheet sent with product.
Application Notes
Specification Recommendation
Recommended Dilution (Conc) 1:25-1:50
Pretreatment Citrate Buffer pH 6.0
Incubation Parameters 30 min at Room Temperature

Prior to use, inspect vial for the presence of any precipitate or other unusual physical properties. These can indicate that the antibody has degraded and is no longer suitable for patient samples. Please run positive and negative controls simultaneously with all patient samples to account and control for errors in laboratory procedure. Use of methods or materials not recommended by enQuire Bio including change to dilution range and detection system should be routinely validated by the user.

Clonality: Monoclonal
Anti-Myeloperoxidase Antibody Clone: 59A5
Host and Isotype: Mouse IgG2b, kappa
Recommended Positive Control Sample: Tonsil
Cellular Localization of Antibody 59A5 Staining: Cytoplasmic
Buffer and Stabilizer: PBS with 1% BSA and 0.05% NaN3
Antibody Concentration: Lot specific. Plese contact tech support for data.
Immunogen: Recombinant protein from exon 7 of the human myeloperoxidase.
Storage Conditions: This antibody should be stored refrigerated (2-8°C). This product should not be used past the expiration date printed on the vial.

Myeloperoxidase Information for Pathologists

Summary:

Staining is either immunohistochemistry (IHC) or enzyme cytochemistry - enzyme cytochemistry is most sensitive and specific stain for myeloid leukemias and granulocytic sarcoma. Stains neutrophils strongly (diffuse granular pattern), other granulocytes variably. Microscopic (histologic) images Missing Image. Myeloid sarcoma of breast.

Limitations and Warranty

This antibody is manufactured in accordance with clinical good manufacturing practices in an ISO13485:2016 certified production facility. It is intended for multiple uses including in vitro diagnostic use and research use only applications. Please see vial label for expiration date. We strive to always deliver antibodies with a shelf life of at least two years.

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Myeloperoxidase [59A5] Antibody (cGMP).