Immunohistochemical staining of Pancreatic Polypeptide  of human FFPE tissue followed by incubation with HRP labeled secondary and development with DAB substrate.

Pancreatic Polypeptide [Polyclonal] Antibody (cGMP).

$ 135.00$ 695.00
Please Select Product Options Below To View The Catalog Number.

SKU: QIVD174
Species: Human
Tested Applications: IHC [IVD]
Available Conjugates:
Isotype: Rabbit Undetermined

Product NumberDescriptionPrice
QIVD174-0.1ml Size: 0.1 ml, Format: Concentrate $ 135.00
QIVD174-0.5ml Size: 0.5 ml, Format: Concentrate $ 415.00
QIVD174-1ml Size: 1 ml, Format: Concentrate $ 695.00
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Datasheets and Documentation
Product Datasheet
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SKU: QIVD174-0.1ml
Pancreatic Polypeptide General Information
Alternate Names
Molecular Weight
10.4 kDa
Chromosomal Location
q21.31 [chr: 17] [chr_start: 43940804] [chr_end: 43942468] [strand: -1]
Curated Database and Bioinformatic Data
Gene SymbolPPY
Entrez Gene ID5539
RefSeq Protein Accession(s)NP_002713
RefSeq mRNA Accession(s)XM_011524978; NM_001319209; NM_002722
RefSeq Genomic Accession(s)NC_000017
UniProt ID(s)P01298
PharmGKB ID(s)PA33690
KEGG Gene ID(s)hsa:5539
General Description of Pancreatic Polypeptide .
This antibody reacts with pancreatic polypeptide. It stains the periphery of islets, exocrine pancreatic parenchyma and the epithelium of small and medium sized ducts and acinar cells.

Antibody (Suitable for clinical applications)

Sample Type: FFPE Patient Samples.
Tested Applications: IHC. Approved for In Vitro Diagnostic Procedures on FFPE tissues. For tissue collection recommendations, please see datasheet sent with product.
Application Notes
Specification Recommendation
Recommended Dilution (Conc) 1:25-1:50
Pretreatment No Pretreatment Required
Incubation Parameters 30 min at Room Temperature

Prior to use, inspect vial for the presence of any precipitate or other unusual physical properties. These can indicate that the antibody has degraded and is no longer suitable for patient samples. Please run positive and negative controls simultaneously with all patient samples to account and control for errors in laboratory procedure. Use of methods or materials not recommended by enQuire Bio including change to dilution range and detection system should be routinely validated by the user.

Clonality: Polyclonal
Anti-Pancreatic Polypeptide Antibody Clone: Polyclonal
Host and Isotype: Rabbit Undetermined
Recommended Positive Control Sample: Pancreas
Cellular Localization of Antibody Polyclonal Staining: Cytoplasmic
Buffer and Stabilizer: PBS with 1% BSA and 0.05% NaN3
Antibody Concentration: Lot specific. Plese contact tech support for data.
Immunogen: Synthetic human pancreatic polypeptide conjugated to keyhole limpet hemocyanin.
Storage Conditions: This antibody should be stored refrigerated (2-8°C). This product should not be used past the expiration date printed on the vial.

Pancreatic Polypeptide Information for Pathologists

Summary:

Pancreatic polypeptide (PP), discovered in 1968 (Endocrinology 1968;83:1323) is a 36 amino acid peptide (molecular weight 4,200 Da) produced and secreted by PP cells (originally termed F cells) of the pancreas. PP cells are primarily located in the Islets of Langerhans and represent about 10% of the islet cells (Virchows Arch A Pathol Anat Histol 1980;387:319). Pathophysiology PP is synthesized as the amino portion of a larger 95 amino acid precursor. The biological activity is located in the carboxyl hexapeptide and requires the C terminal amide.

Common Uses By Pathologists:

PP cells can be identified in pancreatic polypeptide cell hyperplasia (PPCH), PPomas (tumors composed exclusively or mostly of pancreatic polypeptide cells) and mixed pancreatic neuroendocrine tumor. Case reports 32 year old man with malignant pancreatic polypeptide secreting tumour of islet cells (HPB Surg 1993;6:301307). 37 year old woman with pancreatic polypeptide hyperplasia causing watery diarrhea syndrome (Can J Surg 1999;42:55). 46 year old woman with symptomatic pancreatic polypeptide-secreting tumor of the distal pancreas (Int J Gastrointest Cancer 2002;32:153).

Limitations and Warranty

This antibody is manufactured in accordance with clinical good manufacturing practices in an ISO13485:2016 certified production facility. It is intended for multiple uses including in vitro diagnostic use and research use only applications. Please see vial label for expiration date. We strive to always deliver antibodies with a shelf life of at least two years.

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Pancreatic Polypeptide [Polyclonal] Antibody (cGMP).