Formalin-paraffin human Prostate Carcinoma stained with TDP2 MAb (TDP2/1258)
Formalin-paraffin human Prostate Carcinoma stained with TDP2 MAb (TDP2/1258)Formalin-paraffin human Duodenal Carcinoma stained with TDP2 MAb (TDP2/1258)Formalin-paraffin human Colon Carcinoma stained with TDP2 MAb (TDP2/1258)

Anti-TDP2 / EAPII Antibody Clone TDP2/1258

$ 118.00$ 418.00
Please Select Product Options Below To View The Catalog Number.

SKU: 51567-MSM1
Species: Human
Tested Applications: Immunohistochemistry (IHC)
Available Conjugates: Unconjugated
Isotype: Mouse IgG2b kappa
Mass Spec Validated?: Not MS Validated

Product NumberDescriptionPrice
51567-MSM1-P0 Size: 20 ug, Tag: Unconjugated $ 118.00
51567-MSM1-P1 Size: 100 ug, Tag: Unconjugated $ 298.00
51567-MSM1-P2 Size: 200 ug, Tag: Unconjugated $ 418.00
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In Stock.
Flat Rate Shipping Anywhere in the US: $45
Datasheets and Documentation
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SKU: 51567-MSM1-P0
TDP2 / EAPII General Information
Alternate Names
5'-Tyr-DNA phosphodiesterase, EAP2, EAPII, ETS1-associated protein 2, ETS1-associated protein II, TRAF and TNF receptor-associated protein, TTRAP, Tyr-DNA phosphodiesterase 2, Tyrosyl-DNA phosphodiesterase 2 (TDP2), anti-5'-Tyr-DNA phosphodiesterase antibody, anti-EAP2 antibody, anti-EAPII antibody, anti-ETS1-associated protein 2 antibody, anti-ETS1-associated protein II antibody, anti-TRAF and TNF receptor-associated protein antibody, anti-TTRAP antibody, anti-Tyr-DNA phosphodiesterase 2 antibody, anti-Tyrosyl-DNA phosphodiesterase 2 (TDP2) antibody
Molecular Weight
41kDa
Curated Database and Bioinformatic Data
Entrez Gene ID51567
Ensemble Gene IDENSG00000111802
RefSeq Protein Accession(s)NP_057698
RefSeq mRNA Accession(s)NM_016614,
RefSeq Genomic Accession(s)NG_052787, NC_018917, NC_000006
UniProt ID(s)O95551
UniGene ID(s)O95551
HGNC ID(s)17768
Cosmic ID(s)TDP2
KEGG Gene ID(s)hsa:51567
PharmGKB ID(s)PA165618310
General Description of TDP2 / EAPII.
This MAb recognizes a protein of 41kDa, which is identified as TDP2. It is a member of a superfamily of divalent cation-dependent phosphodiesterases. The encoded protein associates with CD40, tumor necrosis factor (TNF) receptor-75 and TNF receptor associated factors (TRAFs), and inhibits nuclear factor-kappa-B activation. This protein has sequence and structural similarities with APE1 endonuclease, which is involved in both DNA repair and the activation of transcription factors. DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 5'-phosphodiester bond, giving rise to DNA with a free 5' phosphate. Catalyzes the hydrolysis of dead-end complexes between DNA and the topoisomerase 2 (TOP2) active site tyrosine residue. Hydrolyzes 5'-phosphoglycolates on protruding 5' ends on DNA double-strand breaks (DSBs) due to DNA damage by radiation and free radicals. The 5'-tyrosyl DNA phosphodiesterase activity can enable the repair of TOP2-induced DSBs without the need for nuclease activity, creating a 'clean' DSB with 5'-phosphate termini that are ready for ligation. Has also 3'-tyrosyl DNA phosphodiesterase activity, but less efficiently and much slower than TDP1. May also act as a negative regulator of ETS1 and may inhibit nuclear factor-kappa-B activation.

Human Anti-TDP2 / EAPII Antibody Product Attributes

Species: Human
Tested Applications: Immunohistochemistry (IHC).
Clonality: Monoclonal
Anti-TDP2 / EAPII Antibody Clone: TDP2/1258
Clone TDP2/1258 Host and Isotype: Mouse IgG2b kappa
Anti-Human TDP2 / EAPII Positive Control Sample: Jurkat cells. Lung, Duodenum or Small Intestinal Carcinoma.
Cellular Localization of Antibody Nuclear ;Cytoplasmic
Buffer and Stabilizer: 10mM PBS with 0.05% BSA and 0.05% Azide
Antibody Concentration: 200 ug/ml
Antibody Purification Method:Protein A/G Purified
Immunogen: Recombinant human full-length TDP2 protein
Storage Conditions: Store at 2 to 8° C (refrigerate). Stable for 24 months when properly stored.

TDP2 / EAPII Previously Observed Antibody Staining Patterns

Observed Subcellular, Organelle Specific Staining Data:

Anti-TDP2 antibody staining is expected to be primarily localized to the nuclear bodies and nucleoplasm. There is variability in either the signal strength or the localization of signal in nuclear bodies from cell to cell.

Limitations and Warranty

enQuire Bio's TDP2 / EAPII Anti-Human Monoclonal is available for Research Use Only. This antibody is guaranteed to work for a period of two years when properly stored.

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Anti-TDP2 / EAPII Antibody Clone TDP2/1258

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