Formalin-fixed, paraffin-embedded human Placenta stained with TIMP2 Monoclonal Antibody (SPM356).
Formalin-fixed, paraffin-embedded human Placenta stained with TIMP2 Monoclonal Antibody (SPM356).

Anti-TIMP2 Antibody Clone SPM356

$ 199.00$ 459.00
Please Select Product Options Below To View The Catalog Number.

SKU: 7077-MSM1X
Species: Human
Tested Applications: Immunohistochemistry (IHC)
Available Conjugates: Unconjugated
Isotype: Mouse IgG2a kappa
Mass Spec Validated?: Not MS Validated

Product NumberDescriptionPrice
7077-MSM1X-P0 Size: 20 ug, Tag: Unconjugated $ 228.00
7077-MSM1X-P1 Size: 100 ug, Tag: Unconjugated $ 488.00
7077-MSM1X-P2 Size: 200 ug, Tag: Unconjugated $ 518.00
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In Stock.
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SKU: 7077-MSM1X-P0
TIMP2 General Information
Alternate Names
Tissue inhibitor of metalloproteinases 2, TIMP2
Molecular Weight
21kDa
Chromosomal Location
17q25
Curated Database and Bioinformatic Data
Gene SymbolTIMP2
Entrez Gene ID7077
Ensemble Gene IDENSG00000035862
RefSeq Protein Accession(s)NP_003246
RefSeq mRNA Accession(s)NM_003255
RefSeq Genomic Accession(s)NC_000017, NC_018928
UniProt ID(s)A0A140VK57, P16035
UniGene ID(s)A0A140VK57, P16035
HGNC ID(s)11821
Cosmic ID(s)TIMP2
KEGG Gene ID(s)hsa:7077
PharmGKB ID(s)PA36527
General Description of TIMP2.
This MAb recognizes a protein of 21kDa, identified as tissue inhibitor of metalloproteinases-2 (TIMP-2). It is closely related to TIMP-1 and shows the highest binding affinity to both the latent (pro) and active forms of 72kDa Type IV collagenase (also known as MMP-2 or gelatinase A). It also has affinity for the active form of 92kDa Type IV collagenase (also known as MMP-9 or gelatinase B). TIMP-2 inhibits the proteolytic invasiveness of tumor cells and normal placental trophoblast cells.

Human Anti-TIMP2 Antibody Product Attributes

Species: Human
Tested Applications: Immunohistochemistry (IHC).
Clonality: Monoclonal
Anti-TIMP2 Antibody Clone: SPM356
Clone SPM356 Host and Isotype: Mouse IgG2a kappa
Anti-Human TIMP2 Positive Control Sample: HeLa cells. Normal Placenta. Breast, Colon, Endometrial, Prostate or Ovarian Carcinoma.
Cellular Localization of Antibody Cytoplasm and Cell Surface
Buffer and Stabilizer: 10mM PBS with 0.05% BSA and 0.05% Azide
Antibody Concentration: 200 ug/ml
Antibody Purification Method:Protein A/G Purified
Immunogen: A synthetic peptide from the N-terminus of human TIMP2 protein (aa56-66) (DSGNDIYGNPI)
Storage Conditions: Store at 2 to 8° C (refrigerate). Stable for 24 months when properly stored.

TIMP2 Previously Observed Antibody Staining Patterns

Observed Antibody Staining Data By Tissue Type:

Variations in TIMP2 antibody staining intensity in immunohistochemistry on tissue sections are present across different anatomical locations. Low, but measureable presence of TIMP2 could be seen inglandular cells in the appendix, hematopoietic cells in the bone marrow, glial cells in the caudate nucleus, neuronal cells in the cerebral cortex, glandular cells in the colon, peripheral nerve/ganglion in colon, glandular cells in the endometrium, squamous epithelial cells in the esophagus, glandular cells in the gallbladder, myocytes in heart muscle, neuronal cells in the hippocampus, hepatocytes in liver, pneumocytes in lung, germinal center cells in the lymph node, non-germinal center cells in the lymph node, respiratory epithelial cells in the nasopharynx, exocrine glandular cells in the pancreas, decidual cells in the placenta, glandular cells in the rectum, myocytes in skeletal muscle, Langerhans in skin, melanocytes in skin, smooth muscle cells in the smooth muscle, adipocytes in mesenchymal tissue, cells in the red pulp in spleen, glandular cells in the stomach, non-germinal center cells in the tonsil and squamous epithelial cells in the vagina. We were unable to detect TIMP2 in other tissues. Disease states, inflammation, and other physiological changes can have a substantial impact on antibody staining patterns. These measurements were all taken in tissues deemed normal or from patients without known disease.

Observed Antibody Staining Data By Tissue Disease Status:

Tissues from cancer patients, for instance, have their own distinct pattern of TIMP2 expression as measured by anti-TIMP2 antibody immunohistochemical staining. The average level of expression by tumor is summarized in the table below. The variability row represents patient to patient variability in IHC staining.

Sample Type breast cancer carcinoid cervical cancer colorectal cancer endometrial cancer glioma head and neck cancer liver cancer lung cancer lymphoma melanoma ovarian cancer pancreatic cancer prostate cancer renal cancer skin cancer stomach cancer testicular cancer thyroid cancer urothelial cancer
Signal Intensity ++ + + + + - ++ + ++ ++ + + + ++ ++ ++ + ++ ++ ++
TIMP2 Variability ++ ++ ++ ++ ++ ++ ++ ++ ++ ++ ++ ++ ++ + + ++ ++ + ++ ++

Limitations and Warranty

enQuire Bio's TIMP2 Anti-Human Monoclonal is available for Research Use Only. This antibody is guaranteed to work for a period of two years when properly stored.

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Anti-TIMP2 Antibody Clone SPM356

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