Formalin-fixed, paraffin-embedded human Thyroid Carcinoma stained with TSHRA Monoclonal Antibody (SPM223).
Formalin-fixed, paraffin-embedded human Thyroid Carcinoma stained with TSHRA Monoclonal Antibody (SPM223).

Anti-TSH-Receptor, A-Chain Antibody Clone SPM223

$ 228.00$ 518.00
Please Select Product Options Below To View The Catalog Number.

SKU: 7253-MSM1X
Species: Human
Tested Applications: Immunohistochemistry (IHC)
Available Conjugates: Unconjugated
Isotype: Mouse IgG1
Mass Spec Validated?: Not MS Validated

Product NumberDescriptionPrice
7253-MSM1X-P0 Size: 20 ug, Tag: Unconjugated $ 199.00
7253-MSM1X-P1 Size: 100 ug, Tag: Unconjugated $ 429.00
7253-MSM1X-P2 Size: 200 ug, Tag: Unconjugated $ 459.00
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In Stock.
Flat Rate Shipping Anywhere in the US: $45
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SKU: 7253-MSM1X-P0
TSH-Receptor, A-Chain General Information
Alternate Names
The thyrotropin receptor, TSH receptor, TSHR
Molecular Weight
62kDa
Chromosomal Location
14q31
Curated Database and Bioinformatic Data
Gene SymbolTSHR
Entrez Gene ID7253
Ensemble Gene IDENSG00000165409
RefSeq Protein Accession(s)XP_005268096, XP_011535421, XP_006720308, NP_001136098, NP_001018046, NP_000360, XP_005268094
RefSeq mRNA Accession(s)XM_005268039, XM_011537119, NM_001018036, NM_001142626, XM_005268037, XM_006720245 NM_000369
RefSeq Genomic Accession(s)NG_009206, NC_018925, NC_000014
UniProt ID(s)A0A0A0MTJ0, P16473
UniGene ID(s)A0A0A0MTJ0, P16473
HGNC ID(s)12373
Cosmic ID(s)TSHR
KEGG Gene ID(s)hsa:7253
PharmGKB ID(s)PA37042
General Description of TSH-Receptor, A-Chain.
Thyroid-stimulating hormone (TSH, also known as thyrotropin) is a glycoprotein involved in the control of thyroid structure and metabolism, which stimulates the release of the thyroid hormones. TSH is regulated by thyroid hormone (T3) and various retinoid compounds. TSH binds to the thyroid-stimulating hormone receptor (TSHR), which is cleaved into two subunits, A and B, and plays a major role in regulating thyroid function. The third cytoplasmic loop of TSHR has been identified as critical for its role in regulating inositol phosphate and cAMP formation. In Graves disease, an autoimmune disorder, TSHR is activated by autoantibodies, which may be stimulated by the cleavage of the A and B subunits.

Human Anti-TSH-Receptor, A-Chain Antibody Product Attributes

Species: Human
Tested Applications: Immunohistochemistry (IHC).
Clonality: Monoclonal
Anti-TSH-Receptor, A-Chain Antibody Clone: SPM223
Clone SPM223 Host and Isotype: Mouse IgG1
Anti-Human TSH-Receptor, A-Chain Positive Control Sample: 293T Cells. Thyroid gland
Cellular Localization of Antibody Cytoplasmic
Buffer and Stabilizer: 10mM PBS with 0.05% BSA and 0.05% Azide
Antibody Concentration: 200 ug/ml
Antibody Purification Method:Protein A/G Purified
Immunogen: Recombinant human TSHR, A-Chain protein
Storage Conditions: Store at 2 to 8° C (refrigerate). Stable for 24 months when properly stored.

TSH-Receptor, A-Chain Previously Observed Antibody Staining Patterns

Observed Antibody Staining Data By Tissue Disease Status:

Tissues from cancer patients, for instance, have their own distinct pattern of TSH-Receptor, A-Chain expression as measured by anti-TSH-Receptor, A-Chain antibody immunohistochemical staining. The average level of expression by tumor is summarized in the table below. The variability row represents patient to patient variability in IHC staining.

Sample Type breast cancer carcinoid cervical cancer colorectal cancer endometrial cancer glioma head and neck cancer liver cancer lung cancer lymphoma melanoma ovarian cancer pancreatic cancer prostate cancer renal cancer skin cancer stomach cancer testicular cancer thyroid cancer urothelial cancer
Signal Intensity + - - - + - - + + - - + + - - - + - - -
TSHR Variability ++ ++ ++ ++ ++ + ++ ++ ++ ++ ++ ++ ++ + ++ ++ ++ + ++ ++

Limitations and Warranty

enQuire Bio's TSH-Receptor, A-Chain Anti-Human Monoclonal is available for Research Use Only. This antibody is guaranteed to work for a period of two years when properly stored.

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Anti-TSH-Receptor, A-Chain Antibody Clone SPM223

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